THE INFLUENCE OF THE ANTIVIRAL DRUGS AMANTADINE AND RIMANTADINE ON ERYTHROCYTE AND PLATELET MEMBRANES AND ITS COMPARISON WITH THAT OF TETRACAINE
THE INFLUENCE OF THE ANTIVIRAL DRUGS AMANTADINE AND RIMANTADINE ON ERYTHROCYTE AND PLATELET MEMBRANES AND ITS COMPARISON WITH THAT OF TETRACAINE
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DOI：
10.1016/0006-2952(87)90355-8
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发表时间：
1987-02-15
影响因子：
5.8
通讯作者：
TAEGER, M
中科院分区：
文献类型：
--
作者：
DONATH, E;HERRMANN, A;TAEGER, M
抗病毒药物金刚烷胺和金刚乙胺以及阴离子类似物 1-金刚烷羧酸对人红细胞膜和血小板的一系列特性的影响与局部麻醉剂丁卡因的作用进行了比较。在低抗病毒药物浓度下，药物诱导红细胞形状变化和抑制渗透性溶血的能力与其临床效力成定量正比（相同浓度下金刚乙胺比金刚烷胺更有效）。金刚乙胺在抑制流感病毒-红细胞融合和病毒引起的溶血方面也比金刚烷胺更有效。抗病毒药物的效果与丁卡因诱导的效果在性质上相似。在定量水平上，丁卡因在抑制渗透性溶血、病毒膜融合和血小板聚集方面比抗病毒药物更有效。在缺乏抗病毒药物作用的任何特异性的情况下，我们主张药物作用的溶酶体模式，即药物通过改变内体或溶酶体 pH 值来改变病毒-膜相互作用。
The influence of the antivirus drugs amantadine and rimantadine and of the anionic analogue 1-adamantane-carboxylic acid on a range of properties of human erythrocyte membrane and of thrombocytes has been compared with the effect of the local anaesthetic tetracaine. At low antiviral drug concentrations the abilities of the drugs to induce erythrocyte shape change and suppress osmotic haemolysis were quantitatively proportional to their clinical potenty (rimantadine more effective than amantadine at the same concentration). Rimantadine was also more effective than amantadine in suppressing influenza virus-erythrocyte fusion and viral induced haemolysis. The antiviral drug effects were qualitatively similar to those induced by tetracaine. At the quantitative level, tetracaine was more efficient than the antiviral drugs in inhibiting osmotic haemolysis, virus membrane fusion and platelet aggregation. In the absence of any specificity of the antiviral drug effects we argue for a lysosomotropic mode of drug action, i.e. that the drugs modify virus-membrane interactions by changing the endosomal or lysosomal pH.