Cytotoxic cucurbitacin constituents from Sloanea zuliaensis.
Cytotoxic cucurbitacin constituents from Sloanea zuliaensis.
复制标题
来自 Sloanea zuliaensis 的细胞毒性葫芦素成分。
DOI：
10.1021/np0303106
复制
发表时间：
2003
影响因子：
5.1
通讯作者：
Gupta,MahabirP
中科院分区：
文献类型：
--
作者：
Rodriguez,Nelson;Vasquez,Yelkaira;Hussein,AhmedA;Coley,PhyllisD;Solis,PabloN;Gupta,MahabirP
A new cucurbitacin D analogue, 2-deoxycucurbitacin D (1), as well as cucurbitacin D (2) and 25-acetylcucurbitacin F (3) were isolated fromSloanea zuliaensis. Compound1was found only in the young leaves of the plant and not in the mature leaves, and its structure was established using spectroscopic means. Compounds1−3demonstrated potent cytotoxic activity against breast (MCF-7), lung (H-460), and central nervous system (SF-268) human cancer cell lines.
