Thermal Induced Modulation of Surface Charge of Sialoglycosphingolipid Micelles
Thermal Induced Modulation of Surface Charge of Sialoglycosphingolipid Micelles
复制标题
唾液酸鞘糖脂胶束表面电荷的热诱导调节
DOI：
10.1021/jp991330c
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发表时间：
1999
影响因子：
3.3
通讯作者：
T. Hayakawa
中科院分区：
文献类型：
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作者：
M. Hirai;and Hiroki Iwase;T. Hayakawa
在本研究中，我们用重标平均球面近似(RMSA)下的壳模拟方法对带电粒子分散体进行了模拟，发现唾液酸鞘糖脂胶束的热结构变化伴随着胶束表面电荷的变化，而表面电荷的变化很大程度上依赖于低聚糖链。在这里，我们治疗三种不同类型的神经鞘糖脂(单唾液神经节苷脂、二唾液神经节苷脂和三唾液神经节苷脂)。这一现象是由生理温度范围20−40°C的温度变化引起的，这与我们最近的报告一致，即神经节苷脂胶束的亲水性部分的热诱导收缩伴随着水的挤出。目前和以前的结果有力地表明，定位于细胞外膜的神经节苷脂分子能够通过富含神经节苷脂的微区局部调节细胞表面的静电荷电势和亲水性。这些功能特性。
In the present study, by using a shell-modeling method under a rescaled mean spherical approximation (RMSA) for charged particle dispersions, we have found that the thermal structural change of sialoglycosphingolipid micelles accompanies a change of the micellar surface charge, which greatly depends on the oligosaccharide chains. Here, we treat three different types of glycosphingolipids (monosialoganglioside, disialoganglioside, and trisialoganglioside). This phenomenon is induced by a variation of temperature in the physiological temperature range 20−40 °C, which is in agreement with our recent reports showing that the thermal induced shrinkage of the hydrophilic portion of the ganglioside micelles accompanies extrusion of water. The present and previous results strongly suggest that ganglioside molecules localized in outer cell membranes are able to modulate locally both electrostatic charge potential and hydrophilicity of cell surfaces through ganglioside-rich microdomains. These functional properties...