Discriminative stimulus effects of N-allylnormetazocine in rats trained to discriminate a kappa from a sigma agonist.
Discriminative stimulus effects of N-allylnormetazocine in rats trained to discriminate a kappa from a sigma agonist.
复制标题
DOI：
10.1016/0024-3205(87)90135-4
复制
发表时间：
1987-01
期刊：
影响因子：
6.1
通讯作者：
B. Slifer;L. Dykstra
中科院分区：
文献类型：
--
作者：
B. Slifer;L. Dykstra
训练大鼠在两级操作任务中辨别乙酮环氮唑(EKC)和车辆、苯环利定(PCP)和苯环利定(PCP)，并在适当的杠杆上按固定比例30计划进行食物强化。这三组分别用训练药物(EKC和PCP)、N-烯丙基去甲氧西林、N-烯丙基去甲氧嘧啶的(+)−和(−)-异构体进行测试。EKC在EKC-Vehicle组和EKC-PCP组产生EKC合适的反应，在PCP-Vehicle组产生车辆合适的反应。同样，PCP在PCP-Vehicle组和EKC-PCP组产生PCP适当的反应，而在EKC-Vehicle组产生Vehicle适当的反应。NANM的(+)-异构体在PCP-VEH和EKC-PCP组中都产生了PCP合适的反应，而(−)-异构体在EKC-VEH和EKC-PCP组中产生了EKC合适的反应。这项研究的结果表明，大鼠可以被训练来区分kappa激动剂和PCP/sigma激动剂，并可以区分其他测试化合物的这些区分刺激特性。这些结果还表明，NANM的(−)-异构体具有kappa激动剂的辨别刺激特性，而(+)-异构体则产生PCP/Sigma样效应。
Rats were trained to discriminate ethylketocyclazocine (EKC) from vehicle, phencyclidine (PCP) from vehicle, or ethylketocyclazocine from phencyclidine on a two-lever operant task with a fixed-ratio 30 schedule of food-reinforcement on the appropriate lever. The three groups wre tested with the training drugs (i.e., EKC and PCP), N-allylnormetazocine (NANM), and the (+)− and (−)-isomers of N-allylnormetazocine. EKC produced EKC-appropriate responding in the EKC-vehicle group and in the EKC-PCP group; it produced vehicle-appropriate responding in the PCP-vehicle group. Similarly, PCP produced PCP-appropriate responding in the PCP-vehicle group and in the EKC-PCP group but vehicle-appropriate responding in the EKC-vehicle group. The (+)-isomer of NANM produced PCP-appropriate responding in both the PCP-VEH and EKC-PCP groups, whereas the (−)-isomer produced EKC appropriate responding in the EKC-VEH and EKC-PCP groups. The results of this study demonstrate that rats can be trained to discriminate a kappa-agonist from a PCP/sigma-agonist and can differentiate these discriminative stimulus properties of other test compounds. These results also indicate that the (−)-isomer of NANM has kappa-agonist discriminative stimulus properties, whereas PCP/sigma-like effects are produced by the (+)-isomer.