Natural history of infection with Bartonella bacilliformis in a nonendemic population
Natural history of infection with Bartonella bacilliformis in a nonendemic population
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DOI：
10.1086/315797
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发表时间：
2000-09-01
影响因子：
6.4
通讯作者：
Cabrera, L
中科院分区：
文献类型：
--
作者：
Kosek, M;Lavarello, R;Cabrera, L
在秘鲁的一个非流行性地区发生巴尔通体病后进行了一项调查。记录急性和慢性巴尔通体病的症状。对55%的受感染人群（554人）进行了血清学分析，其中77.5%的人曾感染过巴尔通体，Oroya热的发病率为13.8%（123例），病死率为0.7%。秘鲁疣的发病率为17.6%。开发了一种新的特异性免疫染色剂，并用于确认B的存在。在活检的皮肤病变中发现杆状病毒。大多数血清反应阳性者（56%）无症状。通过蛋白质印迹法测定，与先前感染相关的症状包括发热（37.2%的血清阳性对17.2%的血清阴性人群; P < .001），骨和关节疼痛（27% vs. 9%; P <0.001），头痛（27% vs. 12.3%; P <0.001），以及描述为秘鲁疣的皮肤病变（26.8% vs. 4.9%; P <0.001）。我们的研究结果表明，感染B。杆状菌引起的疾病范围很广，其严重程度比经常报道的要轻得多。
An investigation was performed after an outbreak of bartonellosis in a region of Peru nonendemic for this disorder. Symptoms of acute and chronic bartonellosis were recorded. Serological analysis was performed on 55% of the affected population (554 individuals), 77.5% of whom demonstrated previous infection with Bartonella bacilliformis, The attack rate of Oroya fever was 13.8% (123 cases); the case-fatality rate was 0.7%. The attack rate of verruga peruana was 17.6%. A new specific immunostain was developed and used to confirm the presence of B. bacilliformis in the biopsied skin lesions. Most seropositive individuals (56%) were asymptomatic. The symptoms that were associated with prior infection, as determined by Western blot, included fever (37.2% of the seropositive vs. 17.2% of the seronegative population; P < .001), bone and joint pain (27% vs. 9%; P < .001), headache (27% vs. 12.3%; P < .001), and skin lesions described as verruga peruana (26.8% vs. 4.9%; P < .001). Our findings suggest that infection with B. bacilliformis causes a broad spectrum of disease that is significantly milder in severity than that frequently reported.