Relationship between the urinary excretion of albumin and retinol-binding protein in insulin-dependent diabetics.
Relationship between the urinary excretion of albumin and retinol-binding protein in insulin-dependent diabetics.
复制标题
胰岛素依赖型糖尿病患者尿白蛋白排泄与视黄醇结合蛋白之间的关系。
DOI：
10.1016/0009-8981(88)90312-9
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
N. Nielsen
中科院分区：
文献类型：
--
作者：
J. Holm;L. Hemmingsen;N. Nielsen
观察糖尿病大鼠肾小球及近端肾小管功能。在胰岛素依赖型糖尿病患者中测定了白蛋白（肾小球功能标志物）和视黄醇结合蛋白（RBP）（低分子量（LMW）蛋白和近端肾小管功能标志物）的尿排泄（相对清除率）。未观察到白蛋白和RBP的相对清除率之间的相关性。在27例患者中观察到无微量白蛋白尿的低分子量蛋白尿，这表明肾小管功能障碍可能是糖尿病肾病发展的早期阶段。16例患者发现微量白蛋白尿，而56例患者存在混合型蛋白尿（微量白蛋白尿和低分子量蛋白尿），其中几例患有晚期肾病，血清RBP和肌酐水平升高。有人建议，肾小管和肾小球功能障碍的组合可能是负责某些情况下的混合性蛋白尿。
The glomerular and proximal tubular function of the diabetic kidney was investigated. The urinary excretion (relative clearance) of albumin, a marker of glomerular function, and retinol binding protein (RBP), a low molecular weight (LMW) protein and marker of proximal tubular function, was determined in insulin-dependent diabetics. No correlation between the relative clearances of albumin and RBP was observed. LMW proteinuria without microalbuminuria was observed in 27 patients which suggests that tubular dysfunction may be an early stage in the development of diabetic nephropathy. Microalbuminuria was found in 16 patients while a mixed type of proteinuria (microalbuminuria and LMW proteinuria) was present in 56 patients several of whom had advanced nephropathy with elevated serum levels of RBP and creatinine. It is suggested that a combination of tubular and glomerular malfunction may be responsible for some cases of mixed proteinuria.