Emergence of embryonic pattern through contact inhibition of locomotion
Emergence of embryonic pattern through contact inhibition of locomotion
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DOI：
10.1242/dev.082248
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发表时间：
2012-12-15
期刊：
影响因子：
4.6
通讯作者：
Stramer, Brian M.
中科院分区：
文献类型：
--
作者：
Davis, John R.;Huang, Chieh-Yin;Stramer, Brian M.
50多年前，细胞生物学家迈克尔·阿伯克龙比（Michael Abercrombie）首次描述了运动的接触抑制过程，当时观察到迁移的成纤维细胞在碰撞时迅速改变方向并迁移。从那以后，我们对接触抑制是如何调节的了解很少，直到最近才观察到它在体内的发生。我们最近发现，果蝇巨噬细胞（血细胞）需要接触抑制其均匀的胚胎扩散。在这里，调查的作用，接触抑制中发挥的图案的血细胞运动，我们已经数学分析和模拟他们的接触排斥动力学。我们的数据表明，血细胞分布的最终模式，其形成的细节和时间，可以解释接触抑制动态内的几何形状的果蝇胚胎。这对一般形态发生有影响，因为它表明，当细胞通过简单的接触排斥规则相互作用时，无论外部线索如何，模式都可以出现。
The pioneering cell biologist Michael Abercrombie first described the process of contact inhibition of locomotion more than 50 years ago when migrating fibroblasts were observed to rapidly change direction and migrate away upon collision. Since then, we have gleaned little understanding of how contact inhibition is regulated and only lately observed its occurrence in vivo. We recently revealed that Drosophila macrophages (haemocytes) require contact inhibition for their uniform embryonic dispersal. Here, to investigate the role that contact inhibition plays in the patterning of haemocyte movements, we have mathematically analysed and simulated their contact repulsion dynamics. Our data reveal that the final pattern of haemocyte distribution, and the details and timing of its formation, can be explained by contact inhibition dynamics within the geometry of the Drosophila embryo. This has implications for morphogenesis in general as it suggests that patterns can emerge, irrespective of external cues, when cells interact through simple rules of contact repulsion.