AH RECEPTOR FOR 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN - COMPARATIVE-STUDIES IN MAMMALIAN AND NONMAMMALIAN SPECIES
AH RECEPTOR FOR 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN - COMPARATIVE-STUDIES IN MAMMALIAN AND NONMAMMALIAN SPECIES
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DOI：
10.1016/0045-6535(86)90452-2
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发表时间：
1986-01-01
期刊：
影响因子：
8.8
通讯作者：
OKEY, AB
中科院分区：
文献类型：
--
作者：
DENISON, MS;WILKINSON, CF;OKEY, AB
在大量不同动物物种的细胞质中鉴定并表征了AhR受体。在所有可检测到受体的物种中，Ah受体的分子特性相似。然而，受体性质的细微差异存在于动物物种之间，这些差异表明，thehrR蛋白在所有物种中是不相同的。目前尚不清楚动物物种之间受体特性的差异是否在确定物种对卤代芳香族化合物毒性的不同敏感性方面发挥重要作用。
TheAhreceptor was identified and characterized in cytosol from a large number of diverse animal species. Molecular properties of theAhreceptor were similar in all species which had detectable receptor. However, subtle differences in receptor properties exist among animal species and these differences indicate that theAhreceptor protein is not identical in all species. It is not yet known whether differences in receptor properties among animal species play a significant role in determining differential susceptibility of the species to toxicity from halogenated aromatic compounds.