Aluminum chloride induced neurofibrillary changes in the developing rabbit: A chronic animal model
Aluminum chloride induced neurofibrillary changes in the developing rabbit: A chronic animal model
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氯化铝诱导发育中兔子的神经原纤维变化：慢性动物模型
DOI：
10.1002/ana.410080505
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发表时间：
1980
影响因子：
11.2
通讯作者：
J. Shek
中科院分区：
文献类型：
--
作者：
H. Wiśniewski;J. Sturman;J. Shek
将氯化铝注入发育中的家兔脑内，可引起脊髓和大脑神经元发生与成年家兔相似的神经病理学变化，沿着除癫痫发作外的多种临床症状。大约一半的兔子存活了三周以上，许多存活了几个月。许多具有大量神经系统改变的兔没有临床体征和症状。氯化铝引起的神经系统的变化的动力学和地形描述了几个月的时间。注射氯化铝后60天，脊髓和大脑神经元内可见大量神经元缠结。神经纤维改变的程度与临床症状和体征的严重程度无明显相关性。在注射氯化铝后85和100天检查的动物有较少的神经元brillary缠结或根本没有，显然它们已经从神经元的变化中恢复过来。这种慢性动物模型将允许更好地研究神经元brillary变化的生物化学和病理学，并且它将使行为研究能够在具有神经元brillary变化的动物中进行。
Aluminum chloride injected into the brains of developing rabbits produced profound neurofibrillary changes in neurons of spinal cord and cerebrum similar to those produced in adult rabbits, along with a variety of clinical symptoms with the exception of seizures. Approximately half of the rabbits survived for more than three weeks, and many survived for several months. Many rabbits with large numbers of neurofibrillary changes had no clinical signs and symptoms. The dynamics and topography of the neurofibrillary changes induced by aluminum chloride are described over a period of several months. Many neurofibrillary tangles were seen in neurons of spinal cord and cerebrum up to 60 days after injection of aluminum chloride. There was no obvious correlation between the degree of neuroftbrillary changes and the severity of the clinical signs and symptoms. Animals examined at 85 and 100 days after injection of aluminum chloride had fewer neuronbrillary tangles or none at all, and apparently they had recovered from the neurofibrillary changes. This chronic animal model will allow better investigations of the biochemistry and pathology of neuronbrillary changes, and it will enable behavioral studies to be performed in animals with neuronbrillary changes.