The role of channel formation in the mechanism of action of tumor necrosis factors.
The role of channel formation in the mechanism of action of tumor necrosis factors.
复制标题
通道形成在肿瘤坏死因子作用机制中的作用。
DOI：
10.1111/j.1749-6632.1993.tb38062.x
复制
发表时间：
1993
影响因子：
5.2
通讯作者：
Wisnieski,B
中科院分区：
文献类型：
--
作者：
Kagan,BL;Mirzabekov,T;Munoz,D;Baldwin,RL;Wisnieski,B
Tumor necrosis factor (TNF) and ly'mphotoxin (Li) are polypeptide cvtokines with pleiotropic effects. They are important in host defense against bacteria, parasites, and viruses, and have inflammatory and metabolic effects. TNF and LT arc also cytotoxins that are selectively toxic for malignant cells. The mechanism of action by which TNF and IT exert these diverse effects remains obscure despite a great deail of effort in this area.TNF has been implicated in the pathophysiology of wasting 1cachexia) and hypcrtrigtyceridcmia. Indeed, it was independently discovered as the hormone (cachetin) responsible for these effects.'TNF plays a key role in regulating the immune response and has been suggested to contribute to a number of rheumatic disorders.'More recently TNF and LH have been implicated in the pathophysiolop-of AIDS (I) AIDS patients often exhibit extreme cachexia and wrasting.(2) l. ahdevirta et al have reported that all AIDS patients, 50% of patients with AIDS-related complex (ARC), and soni patients with lymphadenopathy syndrome have elevated serum levels of TNF (100-200 pg/ml).(3) It has been reported that monocytcs from i IIV-infected patients produce high levels of TNF and lymphocytes from I-tlV-infected patients produce high levels of an LI-like substance.(4) 1N has been reported to activatý, HIV replication in HIV-infected cells. O''(5) Purified 1, T can kill chronically I lV'-infected MOI. 1"-4 cells.(6) AIDS patients are sublect to frequent opportunstic infections and these infectious agents are potent stimulators ofTNF production by mono-
