Natural Animal Populations as Model Systems for Understanding Early Life Adversity Effects on Aging
Natural Animal Populations as Model Systems for Understanding Early Life Adversity Effects on Aging
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DOI：
10.1093/icb/icad058
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发表时间：
2023-06-05
影响因子：
2.6
通讯作者：
Higham，James P.
中科院分区：
文献类型：
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作者：
Patterson，Sam K.;Petersen，Rachel M.;Higham，James P.
在许多物种中，生命早期的不良经历与衰老相关的疾病风险和死亡率有关。在人类中，混杂因素以及直接测量从出生到死亡的经历和结果的困难，使得确定早期生活逆境如何影响衰老和健康具有挑战性。这些挑战可以通过对非人类动物的研究来缓解，这些动物暴露在类似的逆境中，并且可以与人类相似地衰老。此外，研究非人类动物自然种群的早期生活逆境与衰老之间的联系，为更好地了解塑造早期生活敏感性进化的社会和生态压力提供了绝佳的机会。在这里，我们强调了正在进行和未来的研究方向，我们相信这将最有效地有助于我们了解早期生命敏感性的演变及其影响。
Adverse experiences in early life are associated with aging-related disease risk and mortality across many species. In humans, confounding factors, as well as the difficulty of directly measuring experiences and outcomes from birth till death, make it challenging to identify how early life adversity impacts aging and health. These challenges can be mitigated, in part, through the study of non-human animals, which are exposed to parallel forms of adversity and can age similarly to humans. Furthermore, studying the links between early life adversity and aging in natural populations of non-human animals provides an excellent opportunity to better understand the social and ecological pressures that shaped the evolution of early life sensitivities. Here, we highlight ongoing and future research directions that we believe will most effectively contribute to our understanding of the evolution of early life sensitivities and their repercussions.