NF-κB precursor, p105, and NF-κB inhibitor, IκBγ, are both elevated in Alzheimer disease brain
NF-κB precursor, p105, and NF-κB inhibitor, IκBγ, are both elevated in Alzheimer disease brain
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DOI：
10.1016/j.neulet.2004.09.074
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发表时间：
2005-01-10
影响因子：
2.5
通讯作者：
Gong, CX
中科院分区：
文献类型：
--
作者：
Huang, Y;Liu, F;Gong, CX
核因子- kappab （NF-kappaB）信号转导通路调节几个重要的细胞过程。在我们对阿尔茨海默病（AD）相关糖蛋白的研究中，我们发现用凝集素Maackia amurensis凝集素（MAA）染色的45 kda蛋白带显著增加。质谱和Western blot分析表明，这种45 kda的mma阳性蛋白是NF-kappaB的抑制剂。IkappaB-gamma。Western blot分析，IkappaBgamma和NF-kappaB前体的水平。p105，在AD脑K中，与同龄的对照组相比，被发现升高。我们的发现提示NF-kappaB通路可能参与了AD的分子机制。2004爱思唯尔爱尔兰有限公司版权所有。
The nuclear factor-kappaB (NF-kappaB) signal transduction pathway regulates several vital cellular processes. During our studies of the glycoproteins involved in Alzheimer disease (AD), we found a significant increase of a 45-kDa protein band that was stained by lectin Maackia amurensis agglutinin (MAA). Mass spectrometry and Western blot analyses indicated that this 45-kDa MMA-positive protein was an inhibitor of NF-kappaB. IkappaB-gamma. By Western blot analysis, the levels of both IkappaBgamma and NF-kappaB precursor. p105, were found to be elevated in AD brain K, compared to age-matched controls. Our findings suggest that the NF-kappaB pathway might be involved in the molecular mechanism of AD. (C) 2004 Elsevier Ireland Ltd. All rights reserved.