The crosstalk among the physical tumor microenvironment and the effects of glucose deprivation on tumors in the past decade.
The crosstalk among the physical tumor microenvironment and the effects of glucose deprivation on tumors in the past decade.
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DOI：
10.3389/fcell.2023.1275543
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发表时间：
2023
影响因子：
5.5
通讯作者：
Cao X
中科院分区：
文献类型：
--
作者：
Cui Y;Sun Y;Li D;Zhang Y;Zhang Y;Cao D;Cao X
肿瘤的发生和进展与糖代谢密不可分。随着肿瘤的发展，体积逐渐增大，肿瘤的营养供应不能得到充分保证。肿瘤微环境发生改变，缺糖成为肿瘤共同的应激环境。在这里，我们讨论了葡萄糖剥夺和肿瘤微环境的其他特征，如缺氧，免疫逃逸，低pH值和氧化应激之间的相互影响。面对葡萄糖缺乏带来的一系列应激反应，不同类型的肿瘤有不同的应对机制。本文总结了近十年来关于葡萄糖缺乏的肿瘤研究，并对在恶劣条件下决定肿瘤命运的基因和途径进行了综述。事实证明，这些基因中的大多数有助于肿瘤细胞在葡萄糖剥夺条件下存活。相关抑制剂的开发可能为肿瘤的治疗带来新的机遇。
The occurrence and progression of tumors are inseparable from glucose metabolism. With the development of tumors, the volume increases gradually and the nutritional supply of tumors cannot be fully guaranteed. The tumor microenvironment changes and glucose deficiency becomes the common stress environment of tumors. Here, we discuss the mutual influences between glucose deprivation and other features of the tumor microenvironment, such as hypoxia, immune escape, low pH, and oxidative stress. In the face of a series of stress responses brought by glucose deficiency, different types of tumors have different coping mechanisms. We summarize the tumor studies on glucose deficiency in the last decade and review the genes and pathways that determine the fate of tumors under harsh conditions. It turns out that most of these genes help tumor cells survive in glucose-deprivation conditions. The development of related inhibitors may bring new opportunities for the treatment of tumors.
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影响因子：
5.2
作者：
Augustin RC;Delgoffe GM;Najjar YG
通讯作者：
Najjar YG
p53通过调节转谷氨酰胺酶2抵抗葡萄糖代谢应激对胰腺癌糖耐量异常的影响
影响因子：
--
作者：
Su X;He X;Ben Q;Wang W;Song H;Ye Q;Zang Y;Li W;Chen P;Yao W;Yuan Y
通讯作者：
Yuan Y
DOI：
10.1016/j.tem.2018.01.008
发表时间：
2018-04
期刊：
Trends in endocrinology and metabolism: TEM
影响因子：
--
作者：
Buono R;Longo VD
通讯作者：
Longo VD
影响因子：
5.4
作者：
Cham, Candace M.;Driessens, Gregory;O'Keefe, James P.;Gajewski, Thomas F.
通讯作者：
Gajewski, Thomas F.
影响因子：
5.8
作者：
Li YN;Cao YQ;Wu X;Han GS;Wang LX;Zhang YH;Chen X;Hao B;Yue ZJ;Liu JM
通讯作者：
Liu JM