Italian Guidelines for Diagnosis, Prevention, and Treatment of Invasive Fungal Infections in Solid Organ Transplant Recipients
Italian Guidelines for Diagnosis, Prevention, and Treatment of Invasive Fungal Infections in Solid Organ Transplant Recipients
复制标题
DOI：
10.1016/j.transproceed.2011.06.020
复制
发表时间：
2011-07-01
影响因子：
0.9
通讯作者：
Costa, A. Nanni
中科院分区：
文献类型：
--
作者：
Grossi, P. A.;Dalla Gasperina, D.;Costa, A. Nanni
使用各种诱导方案，新的免疫抑制剂，和新的预防策略继续改变实体器官移植（SOT）受者的感染模式。尽管侵袭性真菌感染（IFIs）在该人群中的发生率低于细菌和病毒感染，但它们仍然是全球发病率和死亡率的主要原因。2008年3月，意大利真菌感染和器官移植专家小组在甘多尔福堡（罗马）召开会议，制定SOT接受者IFIs诊断、预防和治疗的共识指南。我们讨论了定义，微生物学和放射学诊断，预防，经验性治疗，和治疗已确定的疾病。在整个共识文件中，根据美国传染病学会和美国公共卫生署的标准评分系统对作为临床指南的建议进行评级。
Use of various induction regimens, of novel immunosuppressive agents, and of newer prophylactic strategies continues to change the pattern of infections among solid organ transplant (SOT) recipients. Although invasive fungal infections (IFIs) occur at a lower incidence than bacterial and viral infections in this population, they remain a major cause of morbidity and mortality worldwide. In March 2008, a panel of Italian experts on fungal infections and organ transplantation convened in Castel Gandolfo (Rome) to develop consensus guidelines for the diagnosis, prevention, and treatment of IFIs among SOT recipients. We discussed the definitions, microbiological and radiological diagnoses, prophylaxis, empirical treatment, and therapy of established disease. Throughout the consensus document, recommendations as clinical guidelines were rated according to the standard scoring system of the Infectious Diseases Society of America and the United Stated Public Health Service.