Body composition in children and adolescents born after in vitro fertilization or spontaneous conception
Body composition in children and adolescents born after in vitro fertilization or spontaneous conception
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DOI：
10.1210/jc.2006-2896
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发表时间：
2007-09-01
影响因子：
5.8
通讯作者：
de Waal, Henriette A. Delemarre-van
中科院分区：
文献类型：
--
作者：
Ceelen, Manon;van Weissenbruch, Mirjam M.;de Waal, Henriette A. Delemarre-van
内容：越来越多的证据表明，产前生活中的不利条件与成年后慢性病的发展有关。目前还不清楚体外受精（IVF）受孕是否会影响人类在早期产前发育期间发生的脆弱发育过程，并长期干扰发育途径。目的：我们的目的是检查8至18岁IVF单胎和自然受孕的对照组的身体组成。设计和设置：这项后续研究在荷兰阿姆斯特丹VU大学医学中心进行。参与者：参与者包括233名IVF儿童（139名青春期儿童）和233名年龄和性别匹配的对照儿童（143名青春期儿童）。主要结果测量：在青春期亚群中，通过人体测量法和双能X线吸收测量法评估身体成分测量。与对照组相比，IVF儿童的肩胛下-三头肌皮褶比显著降低，外周皮褶、外周体重和外周体脂百分比显著升高。虽然没有达到统计学意义，但双能X线吸收法和皮褶厚度测量都表明IVF儿童的全身脂肪增加。无论是当前和早期的危险因素，还是父母因素，如生育力低下的原因，都不能解释体外受精儿童和对照组之间通过人体测量学评估的外周脂肪的差异。IVF儿童和对照组之间的骨矿物质组成没有差异。结论：我们的观察表明，IVF儿童的体脂组成受到干扰。对IVF儿童进行随访以监测从青春期到成年期的体脂模式和潜在相关的健康问题非常重要。
Context: Increasing evidence suggests that adverse conditions during prenatal life are associated with the development of chronic diseases in adult life. It is still unclear whether in vitro fertilization ( IVF) conception could affect the vulnerable developmental processes in humans occurring during early prenatal development with long-term perturbations of developmental pathways.Objective: Our objective was to examine body composition in 8- to 18-yr-old IVF singletons and spontaneously conceived controls born from subfertile parents.Design and Setting: This follow-up study was conducted at the VU University Medical Center in Amsterdam, The Netherlands.Participants: Participants included 233 IVF children ( 139 pubertal children) and 233 age- and gender-matched control children ( 143 pubertal children).Main Outcome Measures: Body composition measures were assessed by anthropometry and dual-energy x-ray absorptiometry in the pubertal subpopulation.Results: IVF children had a significantly lower subscapular-triceps skinfold ratio and a significantly higher sum of peripheral skinfolds, peripheral body mass, and percentage of peripheral body fat as compared with controls. Although not reaching statistical significance, both dual-energy x-ray absorptiometry and skinfold measurements suggested that total body fat in IVF children is increased. Neither current and early risk factors nor parental factors, such as subfertility cause, could explain the differences in peripheral fat assessed by anthropometry between IVF children and controls. No differences in bone mineral composition between IVF children and controls were found.Conclusions: Our observations indicate that body fat composition in IVF children is disturbed. Follow-up of IVF children to monitor body fat pattern and potentially related health problems from adolescence into adulthood is of great importance.