O-Acylation of Tyrosine during Peptide Synthesis
O-Acylation of Tyrosine during Peptide Synthesis
复制标题
肽合成过程中酪氨酸的 O-酰化
DOI：
10.1021/jo01036a515
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发表时间：
1963
影响因子：
3.6
通讯作者：
R. Paul
中科院分区：
文献类型：
--
作者：
R. Paul
在合成血管紧张素II酰胺-1时，在形成缬氨酰-酪氨酸键时遇到了很大的困难。从N，N ′-羰基二咪唑、3· 4-L-酪氨酸酸乙酯和叔丁氧羰基-L-缬氨酸出发，经过多次尝试，才得到50%的产率（后来提高到67%）。6 78910
In the synthesis of angiotensin II amide-1 a great deal of difficulty was encountered in formingthe valyl-tyrosine bond. 1· 2 Only after many attempts were we able toobtain a 50% yield2 (subsequently raised to 67%) of ethyl f-butyloxycarbonyl-L-valyl-L-tyrosinate (I) from N, N'-carbonyldiimidazole, 3· 4 ethyl L-tyrosin-ate5 and t-butyloxy carbonyl-l-valine. 6 78910The