INTERNATIONAL STUDY OF ASTHMA AND ALLERGIES IN CHILDHOOD (ISAAC) - RATIONALE AND METHODS
INTERNATIONAL STUDY OF ASTHMA AND ALLERGIES IN CHILDHOOD (ISAAC) - RATIONALE AND METHODS
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DOI：
10.1183/09031936.95.08030483
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发表时间：
1995-03-01
影响因子：
24.3
通讯作者：
WILLIAMS, HC
中科院分区：
文献类型：
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作者：
ASHER, MI;KEIL, U;WILLIAMS, HC
哮喘和过敏性疾病的病因仍然知之甚少，尽管进行了大量研究，但儿童哮喘和过敏性疾病国际研究(ISAC)成立的目的是通过建立标准化的方法和促进国际合作，最大限度地发挥对哮喘和过敏性疾病的流行病学研究的价值。其具体目标是：1)描述居住在不同中心的儿童中哮喘、鼻炎和湿疹的患病率和严重程度，并在国家内部和国家之间进行比较；2)为评估这些疾病的患病率和严重程度的未来趋势获得基线测量；3)为进一步研究影响这些疾病的遗传、生活方式、环境和医疗保健因素提供一个框架。ISAC设计包括三个阶段，第一阶段使用核心问卷设计，以评估哮喘和过敏性疾病在特定人群中的患病率和严重程度，第二阶段将调查可能的病因，特别是第一阶段研究结果所建议的因素，第三阶段将重复第一阶段以评估患病率趋势。
The aetiology of asthma and allergic disease remains poorly understood, despite considerable research, The International Study of Asthma and Allergies in Childhood (ISAAC), was founded to maximize the value of epidemiological research into asthma and allergic disease, by establishing a standardized methodology and facilitating international collaboration.Its specific aims are: 1) to describe the prevalence and severity of asthma, rhinitis and eczema in children living in different centres, and to make comparisons within and between countries; 2) to obtain baseline measures for assessment of future trends in the prevalence and severity of these diseases; and 3) to provide a framework for further aetiological research into genetic, lifestyle, environmental, and medical care factors affecting these diseases.The ISAAC design comprises three phases, Phase 1 uses core questionnaires designed to assess the prevalence and severity of asthma and allergic disease in defined populations, Phase 2 will investigate possible aetiological factors, particularly those suggested by the findings of Phase 1, Phase 3 will be a repetition of Phase 1 to assess trends in prevalence.