Influence of secretin on the course of acute experimental pancreatitis in rats.
Influence of secretin on the course of acute experimental pancreatitis in rats.
复制标题
促胰液素对大鼠急性实验性胰腺炎病程的影响。
DOI：
10.1159/000198888
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发表时间：
1983
期刊：
影响因子：
3.2
通讯作者：
W. Creutzfeldt
中科院分区：
文献类型：
--
作者：
P. Lankisch;B. Göke;U. Fölsch;K. Winckler;J. Otto;W. Creutzfeldt
抑制胰腺分泌是一种广泛接受的治疗急性胰腺炎的原则。然而，在胰腺炎中，刺激水和碳酸氢盐的分泌可能是有益的，因为它可以冲洗导管系统。牛磺胆酸钠诱导大鼠胰腺炎后，按不同时间间隔给予分泌素（2和16 CU/kg体重）或生理盐水。分泌素治疗后胰腺坏死和水肿稍明显，但分泌素对存活时间、存活率和酶参数没有影响。由此可见，分泌素诱导的胰腺分泌对急性胰腺炎的病程没有影响。
Inhibition of pancreatic secretion is a widely accepted therapeutical principle of acute pancreatitis. However, stimulation of water and bicarbonate secretion may be beneficial by washing out the ductular system in pancreatitis. Secretin (2 and 16 CU/kg body weight) or saline were given to rats at different time intervals after induction of sodium taurocholate pancreatitis. Pancreatic necrosis and edema were slightly more marked after secretin but secretin had no influence on the survival time and rate or enzymatic parameters. It is concluded that in the rat secretin-induced pancreatic secretion does not alter the course of acute pancreatitis.