Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling
Interdigital regulation of digit identity and homeotic transformation by modulated BMP signaling
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DOI：
10.1126/science.289.5478.438
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发表时间：
2000-07-21
期刊：
影响因子：
56.9
通讯作者：
Fallon, JF
中科院分区：
文献类型：
--
作者：
Dahn, RD;Fallon, JF
指定数字身份的发展机制已经引起了30年的强烈兴趣，但仍然知之甚少。在这里，通过小鸡脚发展的实验，我们表明数字身份不是数字原基的固定属性。相反，数字身份是由数字间中胚层指定的，显示了该组织在回归之前的模式功能。更多的后指间表示更多的后数字身份，每个原基将根据接收到的最后的线索发展。此外，手指间骨形态发生蛋白（BMP）信号的抑制可以改变手指身份，表明BMP在这一过程中发挥作用。
The developmental mechanisms specifying digital identity have attracted 30 years of intense interest, but still remain poorly understood, Here, through experiments on chick foot development, we show digital identity is not a fixed property of digital primordia. Rather, digital identity is specified by the interdigital mesoderm, demonstrating a patterning function for this tissue before its regression. More posterior interdigits specify more posterior digital identities, and each primordium will develop in accordance with the most posterior cues received. Furthermore, inhibition of interdigital bone morphogenetic protein (BMP) signaling can transform digit identity, suggesting a role for BMPs in this process.