CD86+1057 G/A Polymorphism and the Risk of Colorectal Cancer
CD86+1057 G/A Polymorphism and the Risk of Colorectal Cancer
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DOI：
10.1089/dna.2009.1003
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发表时间：
2010-07-01
影响因子：
3.1
通讯作者：
Zhang, Lin
中科院分区：
文献类型：
--
作者：
Pan, Xin-Min;Gao, Lin-Bo;Zhang, Lin
CD86(B7-2)是抗原提呈细胞上的一种共刺激分子，不仅在自身免疫和移植中发挥重要作用，而且在肿瘤免疫中也发挥着重要作用。本研究旨在探讨CD86基因多态性是否与结直肠癌(CRC)易感性有关。采用聚合酶链式反应-限制性片段长度多态技术对273例结直肠癌患者和292例健康对照的CD86+1057G/A基因多态性进行分型。CD86基因+1057G/A多态的基因型和等位基因分布在病例组和对照组之间差异有统计学意义。与GG型相比，+1057AA型与结直肠癌的风险显著增加(优势比[OR]=2.16；95%可信区间[CI]，1.31~3.58)。以G等位基因为参照，发现A等位基因的存在与发生结直肠癌的风险显著相关(OR=1.42；95%CI，1.12~1.80)。经分层分析，女性结直肠癌患者的A等位基因频率显著高于男性患者(OR=1.49；95%CI，1.04~2.14)。提示CD86+1057G/A多态可能与中国人群结直肠癌的遗传易感性有关。
CD86 (B7-2), one of the costimulatory molecules on antigen-presenting cells, plays essential roles not only in autoimmunity and transplantation but also in tumor immunity. The purpose of this study was to investigate whether CD86 gene polymorphism was involved in predisposing an individual to colorectal cancer (CRC). The CD86 +1057 G/A polymorphism was genotyped by performing polymerase chain reaction-restriction fragment length polymorphism in 273 patients with CRC and 292 healthy controls. There were significant differences in the genotype and allele distribution of +1057 G/A polymorphism of the CD86 gene between cases and controls. The +1057 AA genotype was associated with a significantly increased risk of CRC when compared with the GG genotype (odds ratio [OR] = 2.16; 95% confidence interval [CI], 1.31-3.58). Using the G allele as a reference, a significant correlation was detected between the presence of the A allele and a risk of developing CRC (OR = 1.42; 95% CI, 1.12-1.80). Interestingly, the A allele in female patients with CRC was significantly higher than that in male patients after stratified analysis (OR = 1.49; 95% CI, 1.04-2.14). These data suggest that CD86 +1057 G/A polymorphism may contribute to genetic susceptibility to CRC in a Chinese population.