Differentiation and proliferation of hematopoietic stem cells.
Differentiation and proliferation of hematopoietic stem cells.
复制标题
DOI：
10.1182/blood.v81.11.2844.bloodjournal81112844
复制
发表时间：
1993-06
期刊：
影响因子：
20.3
通讯作者：
M. Ogawa
中科院分区：
文献类型：
--
作者：
M. Ogawa
现有证据表明，造血干细胞和造血祖细胞的质变，如干细胞自我更新或分化的决定，或多潜能造血祖细胞在分化(承诺)过程中对谱系潜力的选择，是造血干细胞和造血祖细胞的固有属性，本质上是随机的。相反，祖细胞的增殖动力学，即祖细胞的存活和扩张，似乎受到许多相互作用的细胞因子的控制。虽然承诺的祖细胞的增殖和成熟受晚期作用的谱系特异性因子如EP、M-CSF、G-CSF和IL-5的控制，但早期发育阶段的祖细胞受一组重叠的细胞因子控制。IL-3、GM-CSF和IL-4只有在退出G0并开始活跃的细胞增殖后才能调节多潜能祖细胞的增殖。由休眠的原始祖细胞触发周期和维持原始祖细胞的B细胞潜力似乎需要早期作用的细胞因子的相互作用，包括IL-6、G-CSF、IL-11、IL-12、LIF和SF。目前，这个简单的模型符合我们对生长因子与造血祖细胞相互作用的理解。当然，该模型有可能将一个非常复杂的过程过于简单化。然而，由于该模型是可测试的，它有望挑战研究人员设计新的实验来检验其有效性。
Available evidence indicates that qualitative changes in hematopoietic stem cells and progenitors, such as the decision of stem cells to self-renew or differentiate, or selection of lineage potentials by the multipotential progenitors during differentiation (commitment), are intrinsic properties of the progenitors and are stochastic in nature. In-contrast, proliferative kinetics of the progenitors, namely survival and expansion of the progenitors, appear to be controlled by a number of interacting cytokines. While proliferation and maturation of committed progenitors is controlled by late-acting lineage-specific factors such as Ep, M-CSF, G-CSF, and IL-5, progenitors at earlier stages of development are controlled by a group of several overlapping cytokines. IL-3, GM-CSF, and IL-4 regulate proliferation of multipotential progenitors only after they exit from G0 and begin active cell proliferation. Triggering of cycling by dormant primitive progenitors and maintenance of B-cell potential of the primitive progenitors appears to require interactions of early acting cytokines including IL-6, G-CSF, IL-11, IL-12, LIF, and SF. Currently, this simple model fits our understanding of the interactions of growth factors with hematopoietic progenitors. Naturally the model risks oversimplification of a very complex process. However, because the model is testable, it will hopefully challenge investigators to design new experiments to examine its validity.