Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women
Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women
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DOI：
10.1152/ajpendo.2000.278.6.e1144
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发表时间：
2000-06-01
影响因子：
5.1
通讯作者：
Klein, S
中科院分区：
文献类型：
--
作者：
Horowitz, JF;Klein, S
我们测量了8名瘦人[体重指数（BMI）： 21 +/- 1 kg/m(2)]和10名上半身肥胖（UBO）女性（BMI: 38 +/- 1 kg/m(2)）的全身和局部脂溶性和脂肪组织血流量（ATBF）对肾上腺素的敏感性；腰围（100厘米）。所有受试者均接受四期肾上腺素输注（0.00125、0.005、0.0125和0.025 μ g）。Kg脱脂质量（-1）。Min(-1) +胰腺激素钳。采用稳定同位素示踪法测定血浆中全身游离脂肪酸（FFA）和甘油（R-a）含量。采用微透析和氙-133清除率法测定腹腔和股皮下脂肪组织的脂溶活性。肥胖组基础全身FFA R-a和甘油R-a含量分别为449 +/- 31和220 +/- 12 μ mol/min，高于瘦子组（323 +/- 44和167 +/- 21 μ mol/min） （P < 0.05）。肾上腺素输注显著增加瘦肉组FFA R-a和甘油R-a（分别为71 +/- 21%和122 +/- 52%，P < 0.05），而肥胖组无显著升高（分别为7 +/- 6%和39 +/- 10%，P =无统计学意义）。此外，与瘦人相比，肥胖的腹部皮下脂肪组织对肾上腺素的脂溶和ATBF敏感性减弱，而股皮下脂肪组织则没有。我们的结论是，UBO女性对肾上腺素的全身脂溶性敏感性减弱，因为上半身而不是下半身皮下脂肪组织的敏感性降低。
We measured whole body and regional lipolytic and adipose tissue blood flow (ATBF) sensitivity to epinephrine in 8 lean [body mass index (BMI): 21 +/- 1 kg/m(2)] and 10 upper body obese (UBO) women (BMI: 38 +/- 1 kg/m(2); waist circumference >100 cm). All subjects underwent a four-stage epinephrine infusion (0.00125, 0.005, 0.0125, and 0.025 mu g . kg fat-free mass(-1) . min(-1)) plus pancreatic hormonal clamp. Whole body free fatty acid (FFA) and glycerol rates of appearance (R-a) in plasma were determined by stable isotope tracer methodology. Abdominal and femoral subcutaneous adipose tissue lipolytic activity was determined by microdialysis and Xe-133 clearance methods. Basal whole body FFA R-a and glycerol R-a were both greater (P < 0.05) in obese (449 +/- 31 and 220 +/- 12 mu mol/min, respectively) compared with lean subjects (323 +/- 44 and 167 +/- 21 mu mol/min, respectively). Epinephrine infusion significantly increased FFA R-a and glycerol R-a in lean (71 +/- 21 and 122 +/- 52%, respectively; P < 0.05) but not obese subjects (7 +/- 6 and 39 +/- 10%, respectively; P = not significant). In addition, lipolytic and ATBF sensitivity to epinephrine was blunted in abdominal but not femoral subcutaneous adipose tissue of obese compared with lean subjects. We conclude that whole body lipolytic sensitivity to epinephrine is blunted in women with UBO because of decreased sensitivity in upper body but not lower body subcutaneous adipose tissue.