Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension
Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension
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DOI：
10.1183/09031936.03.00057703
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发表时间：
2004-02-01
影响因子：
24.3
通讯作者：
Lohmeyer, J
中科院分区：
文献类型：
--
作者：
Ghofrani, HA;Friese, G;Lohmeyer, J
随着抗逆转录病毒治疗提高了人类免疫缺陷病毒（HIV）感染者的预期寿命，艾滋病毒相关的肺动脉高压这一限制生命的并发症已成为人们关注的焦点。吸入稳定的前列环素类似物伊洛前列素是治疗各种形式的毛细血管前肺动脉高压的有效方法。本研究的主要目的是评估吸入伊洛前列素治疗 HIV 相关性肺动脉高压的安全性和有效性。对 8 例 HIV 感染相关的严重肺动脉高压患者进行了右心和股动脉插管术。研究了氧气、吸入一氧化氮和雾化伊洛前列素的急性作用。 4 例患者接受长期吸入伊洛前列素治疗。肺血管舒张功效排序为伊洛前列素>NO>O-2，肺血管阻力最大降低（平均值+/-+SEM）为30.6+/-3.1%（p
As antiretroviral therapy has improved life expectancy in human immunodeficiency virus (HIV) infection, the life-limiting complication of HIV-related pulmonary hypertension has come into focus. Inhalation of the stable prostacyclin analogue iloprost is an effective treatment for various forms of precapillary pulmonary hypertension. The main objective of the present study was to evaluate the safety and efficacy of inhaled iloprost in HIV-related pulmonary hypertension.In eight patients with severe pulmonary hypertension related to HIV infection, right heart and femoral artery catheterisation were performed. The acute effect of oxygen, inhaled nitric oxide and aerosolised iloprost was investigated. Four patients underwent long-term treatment with inhaled iloprost.The rank order of pulmonary vasodilatory potency was iloprost>NO>O-2, with a maximum reduction (mean+/-+SEM) in pulmonary vascular resistance of 30.6+/-3.1% (p