Neural Remodeling After Myocardial Infarction: The Importance of Heterogeneity.
Neural Remodeling After Myocardial Infarction: The Importance of Heterogeneity.
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心肌梗死后的神经重塑：异质性的重要性。
DOI：
10.1016/j.jacep.2023.05.027
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Fishbein,MichaelC
中科院分区：
文献类型：
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作者：
Chen,Peng-Sheng;Fishbein,MichaelC
除了结构和电生理重塑，心肌梗死（MI）也导致显着的神经重塑。周围神经损伤通过神经发芽触发再生。1然而，过度的再生可能会导致神经支配过度。心肌梗死引起非梗死心肌交感神经切除术。2心交感神经与其他周围神经一样，也经历神经出芽并引起心肌的神经支配过度。3、4神经出芽和交感神经支配亢进，沿着结构和电生理重构，是心肌梗死后室性心律失常和猝死机制的基础。5，6动物模型和人类的交感神经活动（SNA）记录提供了额外的证据，支持神经重塑在心律失常和心脏性猝死机制中的重要性。虽然SNA和猝死之间的关系已经有了很好的记录，但MI后神经重塑的细节仍然不清楚。
In addition to structural and electrophysiological remodeling, myocardial infarction (MI) also leads to significant neural remodeling. Peripheral nerve injury triggers regeneration via nerve sprouting. 1 However, excessive regeneration may cause hyperinnervation. MI produces sympathectomy in noninfarcted myocardium. 2 Like other peripheral nerves, the cardiac sympathetic nerves undergo nerve sprouting and cause hyperinnervation of the myocardium. 3, 4 Nerve sprouting and sympathetic hyperinnervation, along with structural and electrophysiological remodeling, underlie the mechanisms of ventricular arrhythmias and sudden death after MI. 5, 6 Sympathetic nerve activity (SNA) recording in animal models and humans provided additional evidence supporting the importance of neural remodeling in the mechanisms of cardiac arrhythmias and sudden cardiac death. 7, 8 Although the relationship between SNA and sudden death has been well documented, the details of post-MI neural remodeling remains unclear.