SERIES "MATRIX METALLOPROTEINASES IN LUNG HEALTH AND DISEASE" Metalloproteinases in idiopathic pulmonary fibrosis
SERIES "MATRIX METALLOPROTEINASES IN LUNG HEALTH AND DISEASE" Metalloproteinases in idiopathic pulmonary fibrosis
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DOI：
10.1183/09031936.00024711
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发表时间：
2011-12-01
影响因子：
24.3
通讯作者：
Thickett, D. R.
中科院分区：
文献类型：
--
作者：
Dancer, R. C. A.;Wood, A. M.;Thickett, D. R.
在这篇文章中，我们概述了特发性肺纤维化（IPF）中胶原蛋白产生和降解之间平衡的知识现状。与IPF有关的金属蛋白酶的失调作用可能在IPF发病机制中发挥核心作用。因此，抑制IPF中的金属蛋白酶可能具有治疗潜力，但由于动物模型有限和缺乏特异性抑制剂，我们对其病理生理作用的了解受到阻碍。
In this article, we outline the current state of knowledge about the balance between collagen production and degradation in idiopathic pulmonary fibrosis (IPF). The dysregulated action of metalloproteinases implicated in IPF may play a central role in IPF pathogenesis. Inhibiting metalloproteinases in IPF may, therefore, have therapeutic potential, but our knowledge of their pathophysiological role is held back by limited animal models and the lack of specific inhibitors.