Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers
Reversible inside-out micellization of pH-responsive and water-soluble vesicles based on polypeptide diblock copolymers
复制标题
DOI：
10.1021/ja043920g
复制
发表时间：
2005-02-23
影响因子：
15
通讯作者：
Lecommandoux, S
中科院分区：
文献类型：
--
作者：
Rodríguez-Hernández, J;Lecommandoux, S
本文报道了一种新型两性离子二嵌段共聚物聚（L-谷氨酸）-b-聚（L-赖氨酸）（PGA-b-PLys）的合成，并报道了其在中等酸性或碱性水溶液中可逆地自组装成分裂囊泡的过程。这些pH敏感的纳米粒子有望成为大分子纳米生物技术中非常有前途的候选者。
The synthesis of a new zwitterionic diblock copolymer poly(l-glutamic acid)-b-poly(l-lysine) (PGA-b-PLys) is described, and its self-assembly into schizophrenic vesicles that can reversibly be produced in moderate acidic or basic aqueous solutions is reported. These pH-sensitive nanoparticles are expected to be very promising candidates in macromolecular nanobiotechnologies.