Maternal administration of vitamin K does not improve the coagulation profile of preterm infants.
Maternal administration of vitamin K does not improve the coagulation profile of preterm infants.
复制标题
母亲服用维生素 K 不会改善早产儿的凝血功能。
作者：
N. Kazzi;N. Ilagan;K. Liang;G. Kazzi;Ronald L. Poland;Lucille A. Grietsell;Yukihiko Fujii;Yves W. Brans
观察孕妇服用维生素K1对胎龄小于35周的新生儿脐带血凝血酶原时间、活化部分凝血活酶时间、凝血因子II、VII、X活性及凝血因子II、X抗原水平的影响。早产孕妇被随机分配接受10毫克维生素K1肌肉注射或不注射。如果在4天内没有分娩，重复服用维生素K1剂量。在第二次剂量后继续怀孕4天的妇女每天口服20毫克维生素K1，直到怀孕第34周结束。新生儿出生体重370~2550g，胎龄22~34周。两组婴儿的凝血酶原时间、活化部分凝血活酶时间、凝血因子II、VII和X活性以及凝血因子II和X抗原水平均无统计学差异。51名对照组婴儿中有25名发生了脑室出血，47名接受维生素K治疗的婴儿中有25名发生了脑室内出血。对照组婴儿在出生第1天出现III级脑室出血的比例较高(P=.032)，但在出生第3天和第14天，两组婴儿脑室出血的严重程度相似。发生脑室出血的婴儿比没有脑室出血的婴儿明显更小、更年轻、病情更危重。妊娠不到35周的孕妇服用维生素K1并不能改善止血缺陷，也不能降低婴儿脑室出血的发生率或严重程度。
The effect of maternal administration of vitamin K1 on cord blood prothrombin time, activated partial thromboplastin time, activity of factors II, VII, and X, and antigen levels of factors II and X in infants less than 35 weeks' gestation was evaluated. Pregnant women in preterm labor were randomly assigned to receive 10 mg of vitamin K1 intramuscularly or no injection. If delivery did not occur in 4 days, the dose of vitamin K1 was repeated. Women who continued their pregnancy 4 days beyond the second dose received 20 mg of vitamin K1 orally daily until the end of the 34th week of gestation. The birth weights of infants ranged from 370 to 2550 g and gestational age ranged from 22 to 34 weeks. The prothrombin time, activated partial thromboplastin time, factors II, VII, and X activity, and factors II and X antigen levels were not statistically different in either group of infants. Intraventricular hemorrhage occurred in 25 of 51 control infants and 25 of 47 vitamin K-treated infants. More control infants had grade III intraventricular hemorrhage on day 1 (P = .032), but on day 3 and 14 of life, the severity of intraventricular hemorrhage was comparable in both groups. Infants in whom an intraventricular hemorrhage developed were significantly smaller, younger, and more critically ill than infants without intraventricular hemorrhage. Administration of vitamin K1 to pregnant women at less than 35 weeks' gestation does not improve the hemostatic defects nor does it reduce the incidence or severity of intraventricular hemorrhage in their infants.
DOI：
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发表时间：
1988
期刊：
Mead Johnson Symposium on Perinatal and Developmental Medicine
影响因子：
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作者：
Ment,LR
通讯作者：
Ment,LR