Prognostic value of cyclin D1 expression in tumor-free surgical margins in head and neck squamous cell carcinomas
Prognostic value of cyclin D1 expression in tumor-free surgical margins in head and neck squamous cell carcinomas
复制标题
DOI：
10.3109/00016489.2013.795287
复制
发表时间：
2013-08
影响因子：
1.4
通讯作者：
T. Sakashita;A. Homma;Seigo Suzuki;H. Hatakeyama;S. Kano;T. Mizumachi;N. Oridate;S. Fukuda
中科院分区：
文献类型：
--
作者：
T. Sakashita;A. Homma;Seigo Suzuki;H. Hatakeyama;S. Kano;T. Mizumachi;N. Oridate;S. Fukuda
摘要 结论：证明手术切缘cyclin D1阳性状态是局部复发的独立预后指标。无肿瘤手术切缘中cyclin D1的表达可以更好地预测头颈鳞状细胞癌（HNSCC）患者在进行根治性手术治疗后的局部复发。目的：本回顾性研究旨在确定 HNSCC 局部复发的预后指标。方法：共有 116 例接受根治性手术治疗且组织病理学边缘无肿瘤的 HNSCC 患者符合本研究的资格。通过免疫组织化学染色评估手术切缘和肿瘤标本中 p53 和细胞周期蛋白 D1 的表达。结果：总共有 63 名患者（54.3%）的肿瘤标本呈 p53 阳性，34 名患者（29.3%）的切缘呈 p53 阳性。 76 名患者 (65.6%) 的肿瘤标本呈细胞周期蛋白 D1 阳性，54 名患者 (46.6%) 的切缘呈细胞周期蛋白 D1 阳性。在细胞周期蛋白 D1 阳性和阴性边缘的患者之间观察到局部控制率存在显着差异（77.2% vs 91.5%，对数秩检验，p = 0.0139）。多变量 Cox 比例风险测试表明，细胞周期蛋白 D1 阳性边缘局部复发的风险比为 4.58（95% 置信区间 1.14-21.69，p = 0.0304）。
Abstract Conclusion: It was proved that cyclin D1-positive status in surgical margins was an independent prognostic indicator of local recurrence. The expression of cyclin D1 in tumor-free surgical margins may better predict local recurrence in patients with head and neck squamous cell carcinoma (HNSCC) after surgical treatment with curative intent. Objective: This retrospective study aimed to determine the prognostic indicators for local recurrence in HNSCC. Methods: A total of 116 HNSCC patients who underwent surgical treatment with curative intent and had histopathologically tumor-free margins were eligible for this study. The expression of p53 and cyclin D1 was assessed by immunohistochemical staining in surgical margins as well as in tumor specimens. Results: In all, 63 patients (54.3%) had p53-positive tumor specimens and 34 patients (29.3%) had p53-positive margins. Seventy-six patients (65.6%) had cyclin D1-positive tumor specimens and 54 patients (46.6%) had cyclin D1-positive margins. A significant difference in local control rates was observed between patients with cyclin D1-positive and -negative margins (77.2% vs 91.5%, log rank test, p = 0.0139). Multivariate Cox proportional hazards testing indicated that the hazard ratio of cyclin D1-positive margins for local recurrence was 4.58 (95% confidence interval 1.14–21.69, p = 0.0304).