Differential Effects of Dopamine Receptor D1-Type and D2-Type Antagonists and Phase of the Estrous Cycle on Social Learning of Food Preferences, Feeding, and Social Interactions in Mice
Differential Effects of Dopamine Receptor D1-Type and D2-Type Antagonists and Phase of the Estrous Cycle on Social Learning of Food Preferences, Feeding, and Social Interactions in Mice
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DOI：
10.1038/npp.2011.50
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发表时间：
2011-07-01
影响因子：
7.6
通讯作者：
Welsman, Robert G.
中科院分区：
文献类型：
--
作者：
Choleris, Elena;Clipperton-Allen, Amy E.;Welsman, Robert G.
社会学习的神经生物学基础，动物可以“利用他人的专业知识”，避免个体学习的缺点，只是部分理解。我们研究了多巴胺能系统在社会学习中的参与，通过给予多巴胺D1型受体拮抗剂，SCH 23390（0.01，0.05，和0.1毫克/公斤），或D2型受体拮抗剂，雷氯必利（0.1，0.3，和0.6毫克/公斤），成年雌性小鼠之前，社会学习的食物偏好。我们发现，虽然SCH 23390剂量依赖性地抑制社会学习，但不影响进食行为或小鼠区分不同口味饮食的能力，雷氯必利则具有相反的效果，抑制进食，但不影响社会学习。我们发现，食物气味，单独或在社会背景下，是不足以引起食物偏好，证明了这种范式的特定社会性质。发情周期也影响了社会学习，发情前期的小鼠表达社会获得的食物偏好的时间比发情期和非发情期的小鼠长。这表明性腺激素参与，这与已知的雌激素调节女性社会行为和雌激素受体参与社会学习一致。此外，一个详细的行为学分析的社会互动过程中，社会学习的发生表明雷氯必利和动情期引起的变化，在激动的行为，这是没有直接关系的社会学习的影响。总的来说，这些结果表明，D1型和D2型受体的差异参与调节社会学习，喂养，和激动行为，可能是由不同的潜在状态介导的。Neuropsychopharmacology（2011）36，1689-1702; doi：10.1038/npp.2011.50; 2011年4月27日在线发表
The neurobiological bases of social learning, by which an animal can 'exploit the expertise of others' and avoid the disadvantages of individual learning, are only partially understood. We examined the involvement of the dopaminergic system in social learning by administering a dopamine D1-type receptor antagonist, SCH23390 (0.01, 0.05, and 0.1 mg/kg), or a D2-type receptor antagonist, raclopride (0.1, 0.3, and 0.6 mg/kg), to adult female mice prior to socially learning a food preference. We found that while SCH23390 dose-dependently inhibited social learning without affecting feeding behavior or the ability of mice to discriminate between differently flavored diets, raclopride had the opposite effects, inhibiting feeding but leaving social learning unaffected. We showed that food odor, alone or in a social context, was insufficient to induce a food preference, proving the specifically social nature of this paradigm. The estrous cycle also affected social learning, with mice in proestrus expressing the socially acquired food preference longer than estrous and diestrous mice. This suggests gonadal hormone involvement, which is consistent with known estrogenic regulation of female social behavior and estrogen receptor involvement in social learning. Furthermore, a detailed ethological analysis of the social interactions during which social learning occurs showed raclopride- and estrous phase-induced changes in agonistic behavior, which were not directly related to effects on social learning. Overall, these results suggest a differential involvement of the D1-type and D2-type receptors in the regulation of social learning, feeding, and agonistic behaviors that are likely mediated by different underlying states. Neuropsychopharmacology (2011) 36, 1689-1702; doi:10.1038/npp.2011.50; published online 27 April 2011