A HISTOLOGICAL STUDY OF TISSUE-RESPONSE TO SIMULATED CLEFT-PALATE SURGERY AT DIFFERENT AGES IN BEAGLE DOGS
A HISTOLOGICAL STUDY OF TISSUE-RESPONSE TO SIMULATED CLEFT-PALATE SURGERY AT DIFFERENT AGES IN BEAGLE DOGS
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DOI：
10.1016/0003-9969(91)90033-q
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发表时间：
1991-01-01
影响因子：
3
通讯作者：
KUIJPERSJAGTMAN, AM
中科院分区：
文献类型：
--
作者：
WIJDEVELD, MGMM;MALTHA, JC;KUIJPERSJAGTMAN, AM
术后早期和成熟期，在显微镜下研究不同年龄段上颌骨组织对粘骨膜操作的反应。将32只比格犬分为3个实验组，即假手术组和对照组。在6、16或25周龄时，在实验组中，在腭的正中矢状区域切除椭圆形粘骨膜瓣，制作松弛切口，将粘骨膜升高并在中线处闭合，留下两个邻近牙齿的裸露骨区域。在手术后1、2或3周或37周龄时处死动物，并检查颌骨组织的连续切片。手术后两周，疤痕已经形成，它缺乏弹性纤维，表明组织类型更硬。腭骨呈快速骨小梁沉积。牙槽窝中的颈腭和尖颊骨吸收表明牙齿的内侧倾斜。不同的软组织组成持续到成熟。在疤痕组织已经发展的地区，附件通过Sharpey的纤维从粘骨膜腭骨被发现在37周的年龄。因此，牙周瘢痕组织的不同力学性质及其与腭骨的附着可能会影响牙槽骨结构的生长和发育。
The response of maxillary tissues to mucoperiosteal manipulation at different ages was studied microscopically early after operation and at maturity. Thirty-two Beagles were divided into three experimental groups, a sham-operated group and a control group. At the age of 6, 16 or 25 weeks in the experimental groups an elliptical mucoperiosteal flap was excised in the midsagittal region of the palate, relaxation incisions were made and the mucoperiosteum was elevated and closed in the midline leaving two areas of denuded bone adjacent to the teeth. The animals were killed 1, 2 or 3 weeks after the operation or at the age of 37 weeks and serial sections of the jaw tissues were examined. Two weeks after the operation, scar had formed, its lack of elastic fibres indicating a more rigid type of tissue. The palatal bone showed rapid trabecular deposition. Cervico-palatal and apico-buccal bone resorption in the alveolar socket indicated medial tipping of the teeth. The different soft tissue composition persisted until maturity. In the areas where scar tissue had developed, attachment by means of Sharpey's fibres from the mucoperiosteum to the palatal bone was found at the age of 37 weeks. Thus the different mechanical properties of scar tissue adjacent to the teeth and its attachment to the palatal bone may influence the growth and development of dento-alveolar structures.