High mobility group box 1 (HMGB1) protein: possible amplification signal in the pathogenesis of falciparum malaria
High mobility group box 1 (HMGB1) protein: possible amplification signal in the pathogenesis of falciparum malaria
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DOI：
10.1016/j.trstmh.2004.06.008
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发表时间：
2005-03-01
影响因子：
2.2
通讯作者：
Clark, IA
中科院分区：
文献类型：
--
作者：
Alleva, LM;Yang, H;Clark, IA
高迁移率族蛋白盒1（HMGB 1）蛋白是一种DNA结合蛋白，如果从细胞中释放出来，也可以充当促炎细胞因子，是各种形式炎症中的重要放大信号。在16名非洲儿童中，恶性疟疾患者入院时血清中HMGB1的浓度升高，在致命病例中比随后康复的病例中更高（P
High mobility group box 1 (HMGB1) protein, a DNA-binding protein that can also act as a pro-inflammatory cytokine if released from cells, is an important amplification signal in various forms of inflammation. The concentration of HMGB1 in serum taken at admission was increased in falciparum malaria in sixteen African children, more so in fatal cases than in those who subsequently recovered (P