NF-κB regulation: lessons from structures.
NF-κB regulation: lessons from structures.
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DOI：
10.1111/j.1600-065x.2012.01097.x
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发表时间：
2012-03
影响因子：
8.7
通讯作者：
Fusco A
中科院分区：
文献类型：
--
作者：
Ghosh G;Wang VY;Huang DB;Fusco A
指定核因子-κB (NF-κB) 激活的信号传导模块是一个三组分系统：NF-κB、NFκB 抑制剂 (IκB) 和 IκB 激酶复合物 (IKK)。 IKK 接收来自细胞表面或内部的上游信号，并将其自身转化为催化活性形式，从而破坏受抑制的 IκB: NF-κB 复合物中的 IκB，从而使活性 NF-κB 自由调节靶基因。隐藏在这个简单模块中的是家族成员，它们都可以进行各种修改，从而扩展功能范围。代表所有三个组件的三维结构现已可用。这些结构使我们能够用分子术语解释细胞观察结果，同时帮助我们提出新概念，重点了解 NF-κB 激活途径的特异性。
The signaling module that specifies nuclear factor-κB (NF-κB) activation is a three-component system: NF-κB, inhibitor of NFκB (IκB), and IκB kinase complex (IKK). IKK receives upstream signals from the surface or inside the cell and converts itself into a catalytically active form leading to the destruction of IκB in the inhibited IκB: NF-κB complex, leaving active NF-κB free to regulate target genes. Hidden within this simple module are family members that all can undergo various modifications resulting in expansion of functional spectrum. Three-dimensional structures representing all three components are now available. These structures have allowed us to interpret cellular observations in molecular terms and at the same time helped us to bring forward new concepts focused towards understanding the specificity in the NF-κB activation pathway.