CALLOSAL PROJECTIONS IN RAT SOMATOSENSORY CORTEX ARE ALTERED BY EARLY REMOVAL OF AFFERENT INPUT
CALLOSAL PROJECTIONS IN RAT SOMATOSENSORY CORTEX ARE ALTERED BY EARLY REMOVAL OF AFFERENT INPUT
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DOI：
10.1073/pnas.87.4.1396
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发表时间：
1990-02-01
影响因子：
11.1
通讯作者：
KILLACKEY, HP
中科院分区：
文献类型：
--
作者：
KORALEK, KA;KILLACKEY, HP
生后第1周，大鼠体感皮层胼胝体投射神经元的分布由均匀分布变为不连续分布。为了确定这种变化是否受到躯体感觉皮层传入输入的影响，研究了早期单侧眶下神经节和单侧去除背侧丘脑对大鼠躯体感觉皮层胼胝体投射分布的影响。一个月后，上述操作在出生时，胼胝体投射在躯体感觉皮层的切线分布进行了检查，结合逆行和顺行运输辣根过氧化物酶。这两种手法都改变了胼胝体投射神经元和躯体感觉皮层中的终末的分布。眶下神经切断后，对侧初级躯体感觉皮层的胼胝体投射分布发生改变。观察到的异常是一致的丘脑皮质投射的分布改变。此外，在两个半球的第二躯体感觉区的胼胝体投射模式中观察到一致的异常。最值得注意的是，他们是缺席的一部分地区，其中包括代表的mystyrus触须和窦毛在这方面。丘脑消融导致手术侧躯体感觉皮质中的胼胝体投射模式高度异常，在明显随机的位置观察到异常的胼胝体投射带和簇。这些结果被解释为证据表明，外周和中枢输入影响胼胝体投射神经元的分布的成熟变化。
During the first postnatal week, the distribution of callosal projection neurons in the rat somatosensory cortex changes from a uniform to a discontinuous pattern. To determine if this change is influenced by afferent inputs to the somatosensory cortex, the effect of both early unilateral infraorbital nerve section and unilateral removal of the dorsal thalamus on the distribution of callosal projections in rat somatosensory cortex was examined. One month after either of the above manipulations at birth, the tangential distribution of callosal projections in the somatosensory cortex was examined using the combined retrograde and anterograde transport of horseradish peroxidase. Both manipulations alter the distribution of callosal projection neurons and terminations in the somatosensory cortex. After infraorbital nerve section, the distribution of callosal projections is altered in the contralateral primary somatosensory cortex. The abnormalities observed are consistent with the altered distribution of thalamocortical projections. In addition, consistent abnormalities were observed in the pattern of callosal projections of the second somatosensory area of both hemispheres. Most notably, they are absent in a portion of the region that contains the representation of the mystacial vibrissae and sinus hairs in this area. Thalamic ablation resulted in highly aberrant patterns of callosal projections in the somatosensory cortex on the operated side, where abnormal bands and clusters of callosal projections were observed in apparently random locations. These results are interpreted as evidence that both peripheral and central inputs influence the maturational changes in the distribution of callosal projection neurons.