Outcome following surgery for colorectal cancer: analysis by hospital after adjustment for case-mix and deprivation.
Outcome following surgery for colorectal cancer: analysis by hospital after adjustment for case-mix and deprivation.
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DOI：
10.1038/sj.bjc.6600120
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发表时间：
2002-02-01
影响因子：
8.8
通讯作者：
Hole, D J
中科院分区：
文献类型：
--
作者：
McArdle, C S;Hole, D J
结果，调整的情况下，混合和剥夺，在3200例接受切除术的结直肠癌在1991年和1994年之间在苏格兰中部的11家医院进行了研究。各医院之间在老年（P<0.001）和贫困（P<0.0001）患者的比例、就诊方式（P=0.007）和分期（P<0.0001）以及接受明显治愈性切除的患者比例（P<0.001）方面存在显著差异。术后死亡率无显著差异。明显治愈性切除后5年的癌症特异性生存率为59%至76%;姑息性切除后2年的癌症特异性生存率为22%至44%。相应的风险比，调整上述预后因素，明显根治性切除的患者在医院之间的变化从0.58至1.32;和姑息性切除的比率从0.73至1.26。这项研究表明，在调整了病例组合和剥夺的变化后，结直肠癌切除术后医院之间的结果存在显着差异。英国癌症杂志（2002）86，331-335。DOI：10.1038/sj/bjc/6600120 www.bjcancer.com © 2002癌症研究运动
Outcome, adjusted for case-mix and deprivation, in 3200 patients undergoing resection for colorectal cancer in 11 hospitals in Central Scotland between 1991 and 1994 was studied. There were significant differences among individual hospitals in the proportion of elderly (P<0.001) and deprived (P<0.0001) patients, the mode (P=0.007) and stage (P<0.0001) at presentation, and the proportion of patients who underwent apparently curative resection (P<0.001). There were no significant differences in postoperative mortality. Cancer-specific survival at 5 years following apparently curative resection varied from 59 to 76%; cancer-specific survival at 2 years following palliative resection varied from 22 to 44%. The corresponding hazard ratios, adjusted for the above prognostic factors, for patients undergoing apparently curative resection varied among hospitals from 0.58 to 1.32; and the ratios for palliative resection varied from 0.73 to 1.26. This study demonstrates that, after adjustment for variations in case-mix and deprivation, significant differences in outcome among hospitals following resection for colorectal cancer persist. British Journal of Cancer (2002) 86, 331–335. DOI: 10.1038/sj/bjc/6600120 www.bjcancer.com © 2002 The Cancer Research Campaign