Bionic women and men - Part 1: Cardiovascular lessons from heart failure patients implanted with left ventricular assist devices.
Bionic women and men - Part 1: Cardiovascular lessons from heart failure patients implanted with left ventricular assist devices.
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仿生男性和男性 - 第1部分：心力衰竭患者的心血管课程，植入了左心室辅助装置。
DOI：
10.1113/ep088323
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发表时间：
2020-05
影响因子：
2.7
通讯作者：
McDonnell, Barry J.
中科院分区：
文献类型：
--
作者：
Stohr, Eric J.;Cornwell, William K.;Kanwar, Manreet;Cockcroft, John R.;McDonnell, Barry J.
一些慢性晚期心力衰竭患者通过手术植入左心室辅助装置（LVAD）。由于LVAD产生连续的血流，这些患者通常没有脉搏。这使得对人体循环的独特调查和对脉搏“需要”的争议成为可能。这场医学辩论也引发了一场更普遍、更基本的讨论，即什么是“正常”的动脉生理和健康。在静止和活动时，对cf - lvad引起的血流动力学急剧改变的动脉反应的全面研究和理解，提供了一个机会，以一种以前从未研究过的方式，显著增加我们目前对动脉调节基本组成部分（血流、血压、交感神经活动、内皮功能、脉搏）的理解。在一系列四篇文章中，我们总结了在苏格兰阿伯丁举行的2019年生理学会年会上题为“仿生女性和男性-植入式心脏装置的生理学教训”的研讨会上发表的会谈。这些文章强调了在LVAD患者中观察到的生理现象所产生的新问题，并提出了心血管生理学领域未来的兴趣领域。
Some humans with chronic, advanced heart failure are surgically implanted with a left ventricular assist device (LVAD). Because the LVAD produces a continuous flow, a pulse is often absent in these patients. This allows for a unique investigation of the human circulation and a controversy around the ‘need’ for a pulse. This medical debate also generates a more generic, fundamental discussion into what is ‘normal’ arterial physiology & health. The comprehensive study and understanding of the arterial responses to drastically altered haemodynamics due to CF-LVADs, at rest and during activity, presents an opportunity to significantly increase our current understanding of the fundamental components of arterial regulation (flow, blood pressure, sympathetic activity, endothelial function, pulsatility) in a way that could never have been studied previously. In a series of four articles, we summarise the talks presented at the symposium entitled “Bionic Women and Men – Physiology lessons from implantable cardiac devices” during the 2019 Annual Meeting of The Physiological Society in Aberdeen, Scotland. The articles highlight the novel questions generated by physiological phenomena observed in LVAD patients and proposes future areas of interest within the field of cardiovascular physiology.