Race-specific geography of prostate cancer incidence.
Race-specific geography of prostate cancer incidence.
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前列腺癌发病率的特定种族地理。
DOI：
10.1186/1476-072x-5-59
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发表时间：
2006-12-18
影响因子：
4.9
通讯作者：
Samociuk, Holly
中科院分区：
文献类型：
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作者：
DeChello, Laurie M;Gregorio, David I;Samociuk, Holly
本研究评估了康涅狄格州和马萨诸塞州种族特异性前列腺癌发病率的地理分布。这项对人口普查和癌症登记数据的横断面分析包括1994年至1998年间29,040名白人和1,647名非裔美国人诊断为前列腺癌的记录。空间扫描统计用于检测和检验两州区域内种族特异性发病率的地理差异的显著性。在白人和非裔美国男性中，年龄调整后的发病率存在显著的地理差异，分布之间几乎没有重叠。确定的地点反映了居住隔离的模式和社会经济条件。在白人中，发病率高于预期的地方比发病率低于预期的地方具有更高的社会经济地位。在非裔美国人中，社会指标和比率变化之间没有明显的关系。前列腺癌发病率在种族特异性地理分布上的差异并不表明有共同的环境病因。有必要进一步研究影响该病发生和/或报告的遗传、行为和保健因素。这项研究强调需要针对种族和地域的干预措施，以更好地控制高危社区的疾病，并对导致观察到的非洲裔美国人和白人之间癌症发病率差异的社会和背景因素进行持续分析。
This study evaluated geographic distribution of race-specific prostate cancer incidence in Connecticut and Massachusetts. This cross-sectional analysis of census and cancer registry data included records of 29,040 Whites and 1,647 African Americans diagnosed with incident prostate cancer between 1994 and 1998. A spatial scan statistic was used to detect and test significance of the geographic variation in race-specific incidence rates within the two-state area. Significant geographic variation in age-adjusted incidence rates among both White and African American men was observed, with little overlap noted between distributions. Identified locations reflected patterns of residential segregation and socio-economic conditions. Among Whites, places with higher than expected incidence had higher socioeconomic status than places with lower than expected incidence. No discernable relationship between social indicators and rate variation among African Americans was evident. Differences in race-specific geographic distribution of prostate cancer incidence do not suggest a shared environmental etiology. Furtherstudyof genetic, behavioral and health carefactors affecting the occurrence and/or reporting of the disease is warranted. This study highlights the need for race- and geographic-specific interventions to better control disease within at-risk communities and for on-going analysis into social and contextual factors that contribute to observed disparities between African Americans and Whites in the occurrence of cancer.