PBS3 : a versatile player in and beyond salicylic acid biosynthesis in Arabidopsis
PBS3 : a versatile player in and beyond salicylic acid biosynthesis in Arabidopsis
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PBS3：拟南芥水杨酸生物合成中的多才多艺的参与者
DOI：
10.1111/nph.18558
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发表时间：
2023
期刊：
影响因子：
9.4
通讯作者：
Chang, Ming
中科院分区：
文献类型：
--
作者：
Li, Wei;He, Jinyu;Wang, Xiuzhuo;Ashline, Matthew;Wu, Zirui;Liu, Fengquan;Fu, Zheng Qing;Chang, Ming
AVRPPHB易感性3（PBS 3）属于酰基酸酰胺合成酶的GH 3家族，其将氨基酸缀合至不同的酰基酸底物。最近的研究表明，PBS 3抑制剂在植物防御激素水杨酸（SA）的生物合成中起关键作用，催化谷氨酸与异分支酸结合形成异分支酸-9-谷氨酸，然后通过自发衰变或增强的假单胞菌敏感性（EPS 1）催化来产生SA。与其作为SA生物合成的必需酶的功能一致，PBS 3是众所周知的拟南芥植物免疫的正调节剂。此外，PBS 3还通过抑制脱落酸对SA介导的植物免疫的抑制作用，参与非生物和生物胁迫反应之间的权衡。除了胁迫反应，PBS 3还在植物发育中发挥作用。在长日照条件下，PBS 3通过调节开花调节因子FLOWERLOCUS和FLOWERLOCUS T的表达来影响拟南芥的开花时间。综上所述，PBS 3在植物发育和对生物和/或非生物胁迫的响应的信号网络中起作用，但其不同作用的分子机制仍然不清楚。
AVRPPHB SUSCEPTIBLE 3 (PBS3) belongs to the GH3 family of acyl acid amido synthetases, which conjugates amino acids to diverse acyl acid substrates. Recent studies demonstrate that PBS3 inArabidopsisplays a key role in the biosynthesis of plant defense hormone salicylic acid (SA) by catalyzing the conjugation of glutamate to isochorismate to form isochorismate‐9‐glutamate, which is then used to produce SA through spontaneous decay or ENHANCED PSEUDOMONAS SUSCEPTIBILITY (EPS1) catalysis. Consistent with its function as an essential enzyme for SA biosynthesis, PBS3 is well known to be a positive regulator of plant immunity inArabidopsis. Additionally, PBS3 is also involved in the trade‐off between abiotic and biotic stress responses inArabidopsisby suppressing the inhibitory effect of abscisic acid on SA‐mediated plant immunity. Besides stress responses, PBS3 also plays a role in plant development. Under long‐day conditions, PBS3 influencesArabidopsisflowering time by regulating the expression of flowering regulatorsFLOWERING LOCUS CandFLOWERING LOCUS T. Taken together, PBS3 functions in the signaling network of plant development and responses to biotic and/or abiotic stresses, but the molecular mechanisms underlying its diverse roles remain obscure.