Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex
Brain-derived neurotrophic factor alters the synaptic modification threshold in visual cortex
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DOI：
10.1016/s0028-3908(98)00050-1
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发表时间：
1998-04-01
影响因子：
4.7
通讯作者：
Bear, MF
中科院分区：
文献类型：
--
作者：
Huber, KM;Sawtell, NB;Bear, MF
本实验观察了脑源性神经营养因子（BDNF）对幼年大鼠（P21-28）视皮层脑片突触传递及长时程增强（LTP）和长时程抑制（LTD）两种活动依赖性突触可塑性的影响。在BDNF中处理2-5小时的切片显示，当使用“强”强直刺激（θ-爆发刺激）引起最大水平的LTP时，与对照切片没有差异，但在响应“弱”（20 Hz）强直刺激时显示出显著更大的突触增强。BDNF处理过的切片对1 Hz强直刺激的反应也显示出明显较少的LTD。因此，BDNF治疗改变了刺激频率和视皮层突触可塑性之间的关系，使修改阈值向左移动。BDNF对LTP和LTD诱导的影响可能归因于在条件刺激期间观察到的突触反应的显著增强。这些数据表明，BDNF在视皮层发育过程中的作用之一可能是调节突触可塑性的性质，增强突触加强和减少突触弱化过程，这有助于形成特定的突触连接。(C)1998爱思唯尔科技有限公司版权所有。
The effects of brain-derived neurotrophic factor (BDNF) were investigated on synaptic transmission and two forms of activity-dependent synaptic plasticity, long-term potentiation (LTP) and long-term depression (LTD), in visual cortex slices prepared from young (P21-28) rats. The slices treated for 2-5 h in BDNF showed no difference from control slices when a 'strong' tetanus was used (theta-burst stimulation) to elicit a maximal level of LTP but displayed significantly greater synaptic potentiation in response to a 'weak' (20 Hz) tetanus. The BDNF-treated slices also showed significantly less LTD in response to a 1 Hz tetanus. Thus, BDNF treatment alters the relationship between stimulation frequency and synaptic plasticity in the visual cortex, shifting the modification threshold to the left. The effects of BDNF on LTP and LTD induction may be attributed to the significant enhancement of synaptic responses that was observed during conditioning stimulation. These data suggest that one role of BDNF during development of the visual cortex may be to modulate the properties of synaptic plasticity, enhancing synaptic strengthening and reducing synaptic weakening processes which contribute to the formation of specific synaptic connections. (C) 1998 Elsevier Science Ltd. All rights reserved.