Epicardial surface dynamics in the closed-chest normal canine.
Epicardial surface dynamics in the closed-chest normal canine.
复制标题
闭胸正常犬齿的心外膜表面动力学。
DOI：
10.1016/0021-9290(95)00004-2
复制
发表时间：
1995
影响因子：
2.4
通讯作者：
Copenhaver,GL
中科院分区：
文献类型：
--
作者：
McInerney,JJ;Kim,EF;Herr,MD;Copenhaver,GL
过去对心动周期期间闭合胸腔中心脏三维形状变化的研究仅限于测量相对较少的特定位置的局部变形，并且通常需要改变所获得的测量结果的外科手术。在此报告的研究中，使用康普顿反向散射成像技术在心外膜界面获得高精度位移和速度测量，不需要手术干预或造影剂注射。在整个心动周期中，以 13 毫秒的间隔在心外膜界面的 200 多个位置获得位移和速度测量结果。使用该技术测量心动周期期间心脏形状变化的精度可达 0.1 毫米 (S.D.)。本研究中记录的位移和速度模式证实并整合了许多其他研究，并添加了新信息。在等容舒张和早期快速再充盈过程中，左心室 (39 mms-1) 和右心室 (26 mms-1) 表面出现意想不到的剧烈向内运动。在此期间的速度等于或超过喷射期间发生的速度。在射血期间，心脏底部的左心室向内运动比心尖部的左心室运动早 80-90 毫秒。射血时左心室后部的位移和速度是前部和心尖部的 4-6 倍。康普顿反向散射成像技术用于获得闭合胸腔内心脏动力学的不受干扰的测量，有潜力作为心脏表面运动异常的系列研究的非侵入性临床工具。所提供的数据还可用于设置心脏变形生物力学模型的表面边界条件。
Past studies of the changing three-dimensional shape of the heart in the closed chest during the cardiac cycle have been restricted to the measurement of local deformations at a relatively few specific locations, and often have required surgical procedures that alter the measurements obtained. In the study reported here, high precision displacement and velocity measurements were obtained at the epicardial interface using a Compton backscatter imaging technique that does not require a surgical intervention or contrast injections. Displacement and velocity measurements were obtained at more than 200 locations at the epicardial interface at 13 ms intervals throughout the cardiac cycle. Measurements of the changing shape of the heart during the cardiac cycle with this technique are precise to 0.1 mm (S.D.). Displacement and velocity patterns recorded in this study confirm and integrate the studies of many others and also add new information. An unexpected vigorous inward motion of both the LV (39 mms−1) and RV (26 mms−1) surfaces during isovolumic relaxation and early rapid refill is demonstrated. Velocities during this period equal or exceed those that occur during ejection. During ejection, inward LV motion at the base of the heart precedes that at the apex by 80–90 ms. Posterior LV displacements and velocities during ejection are 4–6 times greater than those at the anterior and apex. The Compton backscatter imaging technique for obtaining undisturbed measurements of cardiac dynamics in the closed chest has potential as a non-invasive clinical tool for serial studies of cardiac surface motion abnormalities. The data presented can also be used to set surface boundary conditions for biomechanical models of heart deformation.