Hyperpolarized 3He ventilation defects and apparent diffusion coefficients in chronic obstructive pulmonary disease -: Preliminary results at 3.0 Tesla
Hyperpolarized 3He ventilation defects and apparent diffusion coefficients in chronic obstructive pulmonary disease -: Preliminary results at 3.0 Tesla
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DOI：
10.1097/01.rli.0000262571.81771.66
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发表时间：
2007-06-01
影响因子：
6.7
通讯作者：
Santyr, Giles
中科院分区：
文献类型：
--
作者：
Parraga, Grace;Ouriadov, Alexei;Santyr, Giles
目的：对健康志愿者和慢性阻塞性肺疾病（COPD）患者进行3.0特斯拉超极化He-3磁共振成像（He-3 MRI），以定量评价通气缺陷和表观扩散系数（ADC），并与1.5特斯拉获得的已发表结果进行比较。He-3 ADC和通气缺陷的再现性也进行了评估，在受试者扫描3次，两次在10分钟内，并再次在7 +/- 2天内的第一次MRI vision.Materials和方法：超极化He-3 MRI进行了6例。采集了两张有和没有额外扩散敏化的交错图像，第一张图像用作通气图像，从中测量缺损评分和体积，并将两张图像组合用于计算ADC图和ADC直方图。3.0 T He-3 MRI显示COPD受试者的平均ADC和ADC标准差高于轻中度COPD受试者（0.34 +/- 0.14 cm（2）/s）和重度COPD（0.47 +/- 0.21 cm（2）/s），这些值与先前报告的在1.5特斯拉下获得的结果相似。在所有3次扫描中，平均ADC的重现性较高（重度COPD的变异系数为2%，轻中度COPD为3%，健康志愿者为4%）。较高的同一天的扫描再现性，观察到通气缺陷体积相比，一周的扫描再现性在这一小组subjects.Conclusions：肺气肿肺的ADC值显着增加，与健康的肺在年龄匹配的受试者，和所有的值是可比的，以前报道的在1.5特斯拉。通气缺陷评分和通气缺陷体积结果也与之前在COPD受试者中报告的结果相当。同一天扫描重新扫描和7天重新扫描的ADC重现性较高，与之前报告的结果相似。
Objective: Hyperpolarized He-3 magnetic resonance imaging (He-3 MRI) at 3.0 Tesla of healthy volunteers and chronic obstructive pulmonary disease (COPD) patients was performed for quantitative evaluation of ventilation defects and apparent diffusion coefficients (ADC) and for comparison to published results acquired at 1.5 Tesla. The reproducibility of He-3 ADC and ventilation defects was also assessed in subjects scanned 3 times, twice within 10 minutes, and again within 7 +/- 2 days of the first MRI visit.Materials and Methods: Hyperpolarized He-3 MRI was performed in 6 subjects. Two interleaved images with and without additional diffusion sensitization were acquired with the first image serving as a ventilation image from which defect score and volume were measured and the combination of the 2 images used to compute ADC maps and ADC histograms.Results: He-3 MRI at 3.0 Tesla showed increased mean ADC and ADC standard deviation for subjects with COPD compared with mild-moderate COPD (0.34 +/- 0.14 cm(2)/s), and severe COPD (0.47 +/- 0.21 cm(2)/s), and these values were similar to previously reported results acquired at 1.5 Tesla. Reproducibility of mean ADC was high (coefficient of variation 2% in severe COPD, 3% in mild-moderate COPD, 4% in healthy volunteers) across all 3 scans. Higher same-day scan reproducibility was observed for ventilation defect volume compared with I-week scan reproducibility in this small group of subjects.Conclusions: ADC values for emphysematous lungs were significantly increased compared with healthy lungs in age-matched subjects, and all values were comparable to those reported previously at 1.5 Tesla. Ventilation defect score and ventilation defect volume results were also comparable to results previously reported in COPD subjects Reproducibility of ADC for same-day scan-rescan and 7-day rescan was high and similar to previously reported results.