Pulmonary function is a long-term predictor of mortality in the general population -: 29-year follow-up of the Buffalo Health Study
Pulmonary function is a long-term predictor of mortality in the general population -: 29-year follow-up of the Buffalo Health Study
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DOI：
10.1378/chest.118.3.656
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发表时间：
2000-09-01
期刊：
影响因子：
9.6
通讯作者：
Trevisan, M
中科院分区：
文献类型：
--
作者：
Schünemann, HJ;Dorn, J;Trevisan, M
研究目标：多项研究的结果描述了肺功能与全因和特定原因死亡率之间的关系。本研究的目的是调查 29 年随访后不同性别肺功能的预测价值。设计：对布法罗健康研究队列进行 29 年随访的前瞻性研究。参与者：从纽约州布法罗市所有列出的家庭中随机抽取 554 名男性和 641 名女性样本，年龄 20 至 89 岁。测量和结果：基线测量于 1960 年至1961. 根据以正常预测百分比 (FEV1%pred) 表示的 FEV1 评估肺功能。根据年龄、体重指数、收缩压、教育程度和吸烟状况调整后的 FEV1%pred 与男性和女性的全因死亡率呈负相关 (p < 0.01)。还对参加研究后生存时间至少为 5 年、10 年、15 年、20 年和 25 年的参与者进行了序贯生存分析。除了存活 > 25 个梨的男性外，我观察到 FEV1%pred 与全因死亡率之间存在统计学上显着的负相关关系。 FEV1%pred 也与缺血性心脏病 (IHD) 死亡率呈负相关。当参与者被分为 FEV1%pred 的五分位数时，与 FEV1%pred 最高五分位数的参与者相比，FEV1%pred 最低五分位数的参与者的全因死亡率显着更高。在整个随访期间，男性全因死亡率的调整后风险比分别为 2.24（95% 置信区间 [CI]，1.60 至 3.13），女性为 1.81（95% CI，1.24 至 2.63）。 FEV1%pred 最低五分位数中，男性和女性因 IHD 死亡的风险比分别为 2.11（95% CI，1.20 至 3.71）和 1.90（95% CI，0.99 至 3.88）。 结论：这些结果表明，肺功能是男女总生存率的长期预测因子，可用作一般健康评估的工具。
Study Objectives: Results from several studies have described a relationship between pulmonary function and both all-cause and cause-specific mortality. The purpose of this study was to in investigate the predictive value of pulmonary function by gender after 29 years of follow-up.Design: Prospective study with 29-year follow-up of the Buffalo Health Study cohort.Participants: Randomly selected sample of 554 men and 641 women, aged 20 to 89 years, from all listed households of the city of Buffalo, NY.Measurements and results: Baseline measurements were performed in 1960 to 1961. Pulmonary function was assessed based on FEV1 expressed as the normal percent predicted (FEV1%pred). FEV1%pred adjusted by age, body mass index, systolic BP, education, and smoking status was inversely related to all-cause mortality in both men and women (p < 0.01). A sequential survival analysis in participants who had a survival time of at least 5, 10, 15, 20, and 25 years after enrollment in the study was also performed. Except for men who survived for > 25 pears, me observed a statistically significant negative association between FEV1%pred and all-cause mortality. FEV1%pred was also inversely related to ischemic heart disease (IHD) mortality. When participants were divided into quintiles of FEV1%pred, participants in the lowest quintile of FEV1%pred experienced significantly higher all-cause mortality compared with participants in the highest quintile of FEV1%pred. For the entire follow-up period, the adjusted hazard ratios for all-cause mortality were 2.24 (95% confidence interval [CI], 1.60 to 3.13) for men and 1.81 (95% CI, 1.24 to 2.63) for women, respectively. Hazard ratios for death from IHD in the lowest quintile of FEV1%pred were 2.11 (95% CI, 1.20 to 3.71) and 1.90 (95% CI, 0.99 to 3.88) for men and women, respectively.Conclusions: These results suggest that pulmonary function is a long-term predictor for overall survival rates in both genders and could be used as a tool in general health assessment.