Aberrant transcriptional regulatory network in T cells of multiple sclerosis
Aberrant transcriptional regulatory network in T cells of multiple sclerosis
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DOI：
10.1016/j.neulet.2007.05.056
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发表时间：
2007-07-05
影响因子：
2.5
通讯作者：
Yamamura, Takashi
中科院分区：
文献类型：
--
作者：
Satoh, Jun-ichi;Illes, Zsolt;Yamamura, Takashi
为了确定多发性硬化症（MS）中失调基因的分子网络，我们通过DNA微阵列分析研究了从匈牙利单卵MS双胞胎中分离的纯化CD 3 + T细胞的基因表达谱。通过比较三个一致和一个不一致对，我们确定了20个差异表达基因（DEG）之间的MS患者和遗传相同的健康受试者。通过KeyMolnet综合信息平台分析20 DEG分子网络，发现Ets转录因子家族和核因子NF-κ B与转录调控密切相关。这种新的生物信息学方法提出了一个逻辑假设，即复杂的转录调控网络的异常调控有助于MS中致病性T细胞的发展。（c）2007年爱思唯尔爱尔兰有限公司保留所有权利。
To identify the molecular network of the genes deregulated in multiple sclerosis (MS), we studied gene expression profile of purified CD3+ T cells isolated from Hungarian monozygotic MS twins by DNA microarray analysis. By comparing three concordant and one discordant pairs, we identified 20 differentially expressed genes (DEG) between the MS patient and the genetically identical healthy subject. Molecular network of 20 DEG analyzed by KeyMolnet, a comprehensive information platform, indicated the close relationship with transcriptional regulation by the Ets transcription factor family and the nuclear factor NF-kappa B. This novel bioinformatic approach proposes the logical hypothesis that aberrant regulation of the complex transcriptional regulatory network contributes to development of pathogenic T cells in MS. (c) 2007 Elsevier Ireland Ltd. All rights reserved.