Antioxidant activity of Glossogyne tenuifolia.
Antioxidant activity of Glossogyne tenuifolia.
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Glossogyne tenuifolia 的抗氧化活性。
DOI：
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发表时间：
2005
影响因子：
6.1
通讯作者：
Lisu Wang
中科院分区：
文献类型：
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作者：
Ming;Chian L. Huang;T. Lian;Mei;Lisu Wang
金银花是台湾本土传统的抗炎草药。先前有研究表明，荆芥乙醇提取物（GT）可抑制lps诱导的小鼠巨噬细胞和人全血中炎症介质的释放。在本研究中，荆芥的乙醇提取物及其主要成分木犀草素-7-葡萄糖苷被证明具有清除1,1-二苯基-2-苦酰肼、超氧自由基和羟基自由基的作用。此外，通过降低丙二醛和共轭二烯的形成以及降低电泳迁移率，GT和木犀草素-7-葡萄糖苷抑制了铜诱导的低密度脂蛋白氧化。GT和木犀草素-7-葡萄糖苷对人多形核中性粒细胞和外周血单个核细胞中n-甲氧基-蛋氨酸-亮基-苯丙氨酸诱导的活性氧（ROS）产生也有抑制作用。总之，这些数据表明GT是一种潜在的ROS清除剂，可能通过抑制人白细胞中的LDL氧化或ROS生成来预防动脉粥样硬化。此外，木犀草素-7-葡萄糖苷可能是GT的活性主体。
Glossogyne tenuifolia is a native traditional anti-inflammatory herb in Taiwan. It has previously been shown that the ethanol extract of G. tenuifolia (GT) inhibited the LPS-induced inflammatory mediator release from murine macrophage cell line and human whole blood. In the present work, the ethanol extracts of G. tenuifolia and its major constituent, luteolin-7-glucoside, were shown to be scavengers of 1,1-diphenyl-2-picrylhydrazyl, superoxide, and hydroxyl radicals. Moreover, copper-induced low-density lipoprotein oxidation was suppressed by GT and luteolin-7-glucoside as measured by decreased formation of malondialdehyde and conjugated diene as well as reduced electrophoretic mobility. GT and luteolin-7-glucoside were also against N-formyl-methionyl-leucyl-phenylalanine-induced reactive oxygen species (ROS) production in human polymorphonuclear neutrophils and peripheral blood mononuclear cells. In summary, these data indicated that GT is a potential ROS scavenger and may prevent atherosclerosis via inhibiting LDL oxidation or ROS production in human leukocytes. Moreover, luteolin-7-glucoside may serve as the active principal of GT.
影响因子：
15.9
作者：
BABIOR, BM
通讯作者：
BABIOR, BM