Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C
Double spin-echo sequence for rapid spectroscopic imaging of hyperpolarized 13C
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DOI：
10.1016/j.jmr.2007.05.014
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发表时间：
2007-08-01
影响因子：
2.2
通讯作者：
Vigneron, Daniel B.
中科院分区：
文献类型：
--
作者：
Cunningham, Charles H.;Chen, Albert P.;Vigneron, Daniel B.
用C-13标记的代谢活性化合物的动态核极化已被引入作为体内代谢过程成像的手段。为了区分注射的化合物和各种代谢产物，必须使用一种能够分离不同化学转移种类的成像技术。本文介绍了一种用于超极化C-13快速磁共振成像（MRSI）的脉冲序列的设计和测试。脉冲序列由小尖端激发和双自旋回波组成，双自旋回波采用绝热重聚焦脉冲和“反激”回波平面读出梯度。该序列的关键要素是对发射增益的校准不敏感，形成一个提供高质量光谱信息的自旋回波，以及一个小的有效尖端角，可以在足够的持续时间内保持磁化。体内实验显示三维覆盖，具有良好的光谱质量和信噪比。(c) 2007爱思唯尔公司版权所有。
Dynamic nuclear polarization of metabolically active compounds labeled with C-13 has been introduced as a means for imaging metabolic processes in vivo. To differentiate between the injected compound and the various metabolic products, an imaging technique capable of separating the different chemical-shift species must be used. In this paper, the design and testing of a pulse sequence for rapid magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized C-13 is presented. The pulse sequence consists of a small-tip excitation followed by a double spin echo using adiabatic refocusing pulses and a "flyback" echo-planar readout gradient. Key elements of the sequence are insensitivity to calibration of the transmit gain, the formation of a spin echo giving high-quality spectral information, and a small effective tip angle that preserves the magnetization for a sufficient duration. Experiments in vivo showed three-dimensional coverage with excellent spectral quality and SNR. (c) 2007 Elsevier Inc. All rights reserved.