Plasma 25-hydroxyvitamin D, lung function and risk of chronic obstructive pulmonary disease
Plasma 25-hydroxyvitamin D, lung function and risk of chronic obstructive pulmonary disease
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DOI：
10.1136/thoraxjnl-2013-203682
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发表时间：
2014-01-01
期刊：
影响因子：
10
通讯作者：
Nordestgaard, Borge G.
中科院分区：
文献类型：
--
作者：
Afzal, Shoaib;Lange, Peter;Nordestgaard, Borge G.
25-羟基维生素D （25(OH) D）可能通过调节肺蛋白酶-抗蛋白酶失衡、气道炎症、肺重构和氧化应激与肺功能相关。我们研究了血浆25(OH) D水平与肺功能、肺功能下降和慢性阻塞性肺疾病（COPD）风险的关系。方法对哥本哈根城市心脏研究的10116名参与者和哥本哈根普通人群研究的8391名参与者进行血浆25(OH) D测定。在前一项研究中，长达20年的三次肺功能测量允许分析肺功能下降。结果在两个队列中，25(OH) D的最低十分位数与最高十分位数相比，预测的用力肺活量%降低7%，用力呼气量%降低7-10%。
Background 25-hydroxyvitamin D (25(OH) D) may be associated with lung function through modulation of pulmonary protease-antiprotease imbalance, airway inflammation, lung remodelling and oxidative stress. We examined the association of plasma 25(OH) D levels with lung function, lung function decline and risk of chronic obstructive pulmonary disease (COPD).Methods Plasma 25(OH) D was measured in 10 116 participants in the Copenhagen City Heart Study and in 8391 participants in the Copenhagen General Population Study. In the former study, up to three measurements of lung function spanning 20 years allowed analyses of lung function decline.Results In both cohorts, forced vital capacity in % of predicted was 7% lower and forced expiratory volume in 1 s in % of predicted was 7-10% lower for lowest versus highest decile of 25(OH) D (p(trend)