Fine-scale specificity of cortical networks depends on inhibitory cell type and connectivity
Fine-scale specificity of cortical networks depends on inhibitory cell type and connectivity
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DOI：
10.1038/nn1565
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发表时间：
2005-11-01
影响因子：
25
通讯作者：
Callaway, EM
中科院分区：
文献类型：
--
作者：
Yoshimura, Y;Callaway, EM
兴奋性皮层神经元形成精确互连的神经元的精细网络。在这里，我们测试了大鼠视觉皮层中的抑制性皮层神经元是否也可能与精细尺度特异性相关。使用成对的细胞内记录和光刺激诱发的突触电流的互相关分析，我们发现快速尖峰的中间神经元优先连接到邻近的金字塔，这为它们提供了相互的兴奋。此外，只有当两个细胞相互连接时，它们才与邻近的锥体神经元共享共同的精细兴奋性输入，而不是在没有连接或单向的抑制性到兴奋性连接时。适应抑制神经元与邻近的金字塔很少或根本没有共同的输入，无论它们的直接连接如何。我们得出的结论是，与抑制性神经元的抑制性连接和兴奋性连接都可以在精细范围内精确。此外，精细尺度特异性取决于抑制神经元的类型以及相邻锥体抑制神经元对之间的直接连接。
Excitatory cortical neurons form fine-scale networks of precisely interconnected neurons. Here we tested whether inhibitory cortical neurons in rat visual cortex might also be connected with fine-scale specificity. Using paired intracellular recordings and cross-correlation analyses of photostimulation-evoked synaptic currents, we found that fast-spiking interneurons preferentially connected to neighboring pyramids that provided them with reciprocal excitation. Furthermore, they shared common fine-scale excitatory input with neighboring pyramidal neurons only when the two cells were reciprocally connected, and not when there was no connection or a one-way, inhibitory-to-excitatory connection. Adapting inhibitory neurons shared little or no common input with neighboring pyramids, regardless of their direct connectivity. We conclude that inhibitory connections and also excitatory connections to inhibitory neurons can both be precise on a fine scale. Furthermore, fine-scale specificity depends on the type of inhibitory neuron and on direct connectivity between neighboring pyramidal-inhibitory neuron pairs.