MATERNAL VITAMIN-D INTAKE AND MINERAL METABOLISM IN MOTHERS AND THEIR NEWBORN-INFANTS
MATERNAL VITAMIN-D INTAKE AND MINERAL METABOLISM IN MOTHERS AND THEIR NEWBORN-INFANTS
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DOI：
10.1136/bmj.281.6232.11
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发表时间：
1980-01-01
影响因子：
--
通讯作者：
POCOCK, SJ
中科院分区：
文献类型：
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作者：
COCKBURN, F;BELTON, NR;POCOCK, SJ
从怀孕第12周开始每天补充400 IU（10微克）维生素D2的孕妇在24周时血浆钙浓度较高，但在分娩时与未接受补充剂的对照孕妇相似。接受补充剂的妇女的婴儿在出生后第六天的钙浓度较高，磷浓度较低，镁浓度相似，低钙血症的发生率低于对照妇女的婴儿。治疗组母亲和婴儿的25-羟基胆钙化醇血浆浓度较高，显示出季节性变化。脐带血钙、镁、磷和25-羟基胆钙化醇浓度与分娩时母体值相关。母乳喂养的婴儿比人工喂养的婴儿有更高的钙和镁，更低的磷和25-羟基胆钙化醇浓度。在对照组妇女所生的婴儿（其中许多人患有低钙血症）中发现牙釉质缺陷的比例很高。这些结果表明，在怀孕期间补充维生素D对母亲是有益的，因为她们每天从饮食和皮肤合成中摄入的维生素D明显低于500 IU。
Pregnant women receiving daily supplements of 400 IU (10 microgram) of vitamin D2 from the 12th week of pregnancy had plasma calcium concentrations higher at 24 weeks but similar at delivery to those in control pregnant women who did not receive the supplements. Infants of the women receiving the supplements had higher calcium, lower phosphorus, and similar magnesium concentrations on the sixth day of life and a lower incidence of hypocalcaemia than infants of the control women. Plasma concentrations of 25-hydroxycholecalciferol, which showed a seasonal variation, were higher in mothers and infants in the treated group. Cord-blood calcium, magnesium, phosphorus, and 25-hydroxycholecalciferol concentrations correlated with maternal values at delivery. Breast-fed infants had higher calcium and magnesium and lower phosphorus and 25-hydroxycholecalciferol concentrations than artificially fed infants. A defect of dental enamel was found in a high proportion of infants (many of whom had suffered from hypocalcaemia) born to the control women. These results suggest that vitamin D supplementation during pregnancy would be beneficial for mothers, whose intake from diet and skin synthesis is appreciably less than 500 IU of vitamin D daily.