Characterization of a novel human pre-B leukemia cell line.
Characterization of a novel human pre-B leukemia cell line.
复制标题
新型人类前 B 白血病细胞系的表征。
作者：
R. G. Smith;V. Dev;W. Shannon
一种新的人前b细胞系的衍生，从白血病期的女孩淋巴母细胞淋巴瘤的白细胞报道。该细胞系被称为SMS-SB，能合成mu链，但不能合成轻链。这些mu-链只存在于细胞质中，不分泌。SMS-SB细胞携带HLA-DR决定因子。它们不表达常见的ALL抗原或末端脱氧核苷酸转移酶，因此与先前描述的人类前b白血病细胞系不同。SMS-SB细胞类似于某些Abelson白血病病毒转化的小鼠骨髓细胞。除了缺乏形成的小鼠骨髓细胞。除了缺乏mu分泌外，SMS-SB细胞的表型与骨髓前b细胞的主要亚群相同。
The derivation of a new human pre-B cell line from the leukocytes of a girl in the leukemic phase of lymphoblastic lymphoma is reported. Cells of this line, termed SMS-SB, synthesized mu but not light chains. These mu-chains were found only in the cytoplasm and were not secreted. SMS-SB cells bore HLA-DR determinants. They did not express the common ALL antigen or terminal deoxynucleotidyl transferase and, therefore, differed from previously described human pre-B leukemia cell lines. SMS-SB cells resembled certain Abelson leukemia virus-transformed mouse bone marrow cells. Except for the lack of formed mouse bone marrow cells. Except for the lack of mu secretion, the phenotype of SMS-SB cells was the same as the major subpopulation of marrow pre-B cells.