Chronological changes of serum exosome in preterm infants: A?prospective study
Chronological changes of serum exosome in preterm infants: A?prospective study
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早产儿血清外泌体的时间变化：前瞻性研究
DOI：
10.1111/ped.14933
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发表时间：
2022
影响因子：
1.4
通讯作者：
Maruo Yoshihiro
中科院分区：
文献类型：
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作者：
Ohta Motoki;Koshida Shigeki;Jimbo Itsuki;Oda Machi;Inoue Ryo;Tsukahara Takamitsu;Terahara Masaki;Yanagi Takahide;Nakahara Sayuri;Shibata Masami;Tsutsui Hidemi;Yoshida Daisuke;Furukawa Ouki;Maruo Yoshihiro
背景外泌体是一种存在于包括血清在内的所有体液中的纳米级细胞外囊泡，具有细胞间通讯的机制。最近讨论了外泌体在新生儿疾病中的潜在临床应用。然而，在早期infantation.MethodsIn这项前瞻性研究中，血清中的exosomes的特点，我们评估了20名婴儿出生后12个月的血清来源的exosomes的浓度的时间变化。结果血清来源的exosomes的平均浓度为4.6 × 1010粒子/mL出生时，并显着增加，直到48周的年龄。出生时（r = 0.54，P = 0.01）和出生后8周（r= 0.48，P < 0.001）血清来源的exosomes浓度与胎龄之间存在中度相关性。多变量分析显示，出生时胎龄与出生时血清源性外泌体浓度相关（偏回归系数，0.86; 95%置信区间，0.37-1.37;P= 0.002）。结论早产儿血清源性外泌体浓度在出生后按时间顺序和胎龄增加。这些基本数据可能有助于进一步了解早产儿中外泌体的生理学。
BackgroundExosomes, which are observed in all human fluid, including serum, are nanosized extracellular vesicles with a mechanism of intercellular communication. Potential clinical applications of exosomes in neonatal diseases have recently been discussed. However, the characteristics of exosomes in serum during early infancy is unclear.MethodsIn this prospective study, we evaluated the chronological changes in the concentration of serum‐derived exosomes of 20 infants for 12 months after birth.ResultsThe average concentration of serum‐derived exosomes was 4.6 × 1010particles/mL at birth and increased significantly until the age of 48 weeks. There was a moderate correlation between the gestational age and the concentration of serum‐derived exosomes both at birth (r= 0.54,P= 0.01) and during the 8 weeks after birth (r= 0.48,P< 0.001). A multivariable analysis showed that gestational age at birth was associated with the concentration of serum‐derived exosomes at birth (partial regression coefficient, 0.86; 95% confidence interval, 0.37–1.37;P= 0.002).ConclusionsThe concentration of serum‐derived exosomes in preterm infants increased both chronologically and by gestational age after birth. These basic data may help to further understand physiology of exosomes in preterm infants.