IL-10-producing CD4(+) T cells negatively regulate fucosylation of epithelial cells in the gut.
IL-10-producing CD4(+) T cells negatively regulate fucosylation of epithelial cells in the gut.
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DOI：
10.1038/srep15918
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发表时间：
2015-11-02
影响因子：
4.6
通讯作者：
Kiyono H
中科院分区：
文献类型：
--
作者：
Goto Y;Lamichhane A;Kamioka M;Sato S;Honda K;Kunisawa J;Kiyono H
上皮细胞（EC）表面的岩藻糖基化聚糖通过作为附着受体和某些细菌的营养来源来调节肠道内稳态。我们在这里表明，回肠上皮岩藻糖基化是负调控的IL-10产生的CD 4 + T细胞。缺乏T细胞的小鼠回肠中岩藻糖基化EC的数量增加，特别是表达αβ T细胞受体（TCR）、CD 4和IL-10的小鼠。在缺乏B细胞的小鼠中没有观察到这种效应。从正常小鼠连续转移αβTCR+ CD 4 + T细胞，而不是IL-10缺陷小鼠，使EC的岩藻糖基化正常化。这些发现表明，IL-10产生的CD 4 + T细胞有助于维持内皮细胞的功能，通过调节其岩藻糖基化。
Fucosylated glycans on the surface of epithelial cells (ECs) regulate intestinal homeostasis by serving as attachment receptors and a nutrient source for some species of bacteria. We show here that epithelial fucosylation in the ileum is negatively regulated by IL-10-producing CD4+ T cells. The number of fucosylated ECs was increased in the ileum of mice lacking T cells, especially those expressing αβ T cell receptor (TCR), CD4, and IL-10. No such effect was observed in mice lacking B cells. Adoptive transfer of αβTCR+ CD4+ T cells from normal mice, but not IL-10-deficient mice, normalized fucosylation of ECs. These findings suggest that IL-10-producing CD4+ T cells contribute to the maintenance of the function of ECs by regulating their fucosylation.